alexa Drugs and Orthostatic Hypotension: Evidence from Literature | OMICS International | Abstract
ISSN: 2167-1095

Journal of Hypertension: Open Access
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Review Article

Drugs and Orthostatic Hypotension: Evidence from Literature

Valeria Milazzo1*, Cristina Di Stefano1, Serena Servo2, Valentina Crudo1, Chiara Fulcheri1, Simona Maule1 and Franco Veglio1

1Autonomic Unit and Hypertension Unit, Department of Medicine and Experimental Oncology, S. Giovanni Battista Hospital, University of Turin, Turin, Italy

2Department of Neurology, Maggiore Della Carità Hospital, Eastern Piedmont University, Novara, Italy

*Corresponding Author:
Dr. Valeria Milazzo
SCDU Medicina 4, Azienda Ospedaliera S. Giovanni Battista
Corso Bramante 88, 10126 Torino, Italy
Tel: 390 116 336 959
Fax: 390 116 336 931
E-mail: [email protected]

Received Date: March 03, 2012; Accepted Date: March 23, 2012; Published Date: March 26, 2012

Citation: Milazzo V, Stefano CD, Servo S, Crudo V, Fulcheri C, et al. (2012) Drugs and Orthostatic Hypotension: Evidence from Literature. J Hypertens 1:104. doi:

Copyright: © 2012 Milazzo V, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Orthostatic hypotension is defined as the reduction of systolic blood pressure of at least 20 mmHg or the dropping of diastolic blood pressure of at least 10 mmHg within 3 minutes of standing compared to baseline values. It can be divided into neurogenic and non neurogenic forms. Neurogenic forms are caused by a primitive damage to autonomic nervous system, while drugs are the most common cause of non neurogenic orthostatic hypotension; they may also complicate or aggravate neurogenic forms. Many drugs can determine orthostatic hypotension, including both cardiovascular drugs and therapies used for neurological and psychiatric disorders. This effect is furthermore enhanced by multiple pharmacological treatments. It is important for the clinician to know the potential hazard of orthostatic hypotension, in order to avoid syncope, falls, hypoperfusion symptoms, excess of mortality and loss of compliance to treatment.


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