alexa Dual Role of Inflammation in Prognosis and Prevention of Tuberculosis
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
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Review Article

Dual Role of Inflammation in Prognosis and Prevention of Tuberculosis

Shahnawaz Majeed1, Shabir Ahmad Mir2 and Sadhna Sharma1*
1Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh -160012, India
2Department of Biochemistry, University of Pretoria, Pretoria 0028, South Africa
Corresponding Author : Sadhna Sharma
Department of Biochemistry
PGIMER, Chandigarh-160012 (India)
Tel: 91-0172-2755180
Fax: 91-0172-2745078 2744401
E-mail: [email protected]
Received: January 02, 2015; Accepted: February 17, 2015; Published: February 24, 2015
Citation: Majeed S, Ahmad MS, Sharma S (2015) Dual Role of Inflammation in Prognosis and Prevention of Tuberculosis. J Clin Cell Immunol 6:298. doi: 10.4172/2155-9899.1000298
Copyright: ©2015 Sharma S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

The high death rate and progressive spread of tuberculosis emphasizes the need to address the complexities associated with the disease and its treatment. Complications associated with the disease are associated with the process of inflammation. Host defense system protects the body against pathogen by various inflammatory responses and the same are utilized by the pathogen as an offensive tool to progress inside the host. The genetic factors which determine the expression of inflammatory markers affect the onset of the disease and its treatment. The susceptibility to infection, progression to active or latent form and dissemination to the other sites are governed by the inflammatory responses generated by the host. The prognosis of tuberculosis is not the pathogenic infection but the outcome of the host- pathogen interactions, most of which are still not understood. In this review we discuss the major host inflammatory responses during Mycobacterium tuberculosis infection and their role in progression and/or containment of the infection. In addition the possible role of anti-inflammatory drugs as adjunct to the current anti-tuberculosis treatment will be reviewed.

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