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Duration of the Surgery and Age are Risk Factors for QTc Interval Prolongation under General Anaesthesia with Volatile Anesthetics | OMICS International | Abstract
ISSN: 2155-6148

Journal of Anesthesia & Clinical Research
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Research Article

Duration of the Surgery and Age are Risk Factors for QTc Interval Prolongation under General Anaesthesia with Volatile Anesthetics

Beverly Waxler1*, Bosko Margeta2, Luminita Tureanu3 and Louis Fogg4

1Department of Anesthesiology, John H. Stroger Hospital of Cook County, USA

2Departments of Cardiology, John H. Stroger Hospital of Cook County & Rush University Medical Center, USA

3Department of Anesthesiology, Northwestern University's Feinberg School of Medicine, USA

4Department of Psychology, Rush University Medical Center, USA

*Corresponding Author:
Beverly Waxler
Voluntary Physician, Department of Anesthesiology
5th Floor, John H. Stroger Hospital of Cook County
1901 West Harrison St, Chicago, IL 60612, USA
Fax: 1-847-675-2280
E-mail: [email protected]

Received date: May 19, 2012; Accepted date: October 22, 2012; Published date: October 30, 2012

Citation: Waxler B, Margeta B, Tureanu L, Fogg L (2012) Duration of the Surgery and Age are Risk Factors for QTc Interval Prolongation under General Anesthesia with Volatile Anesthetics. J Anesth Clin Res 3:254. doi: 10.4172/2155-6148.1000254

Copyright: © 2012 Waxler B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Background: Prolongation of the QT interval signals disordered cardiac repolarization which poses a significant risk to patients undergoing surgical procedures under anesthesia. Methods: This study analyzed the demographic, clinical, and pharmacological factors in relation to QT interval prolongation under different types of anesthesia. This prospective observational study compared demographic characteristics, clinical and pharmacological factors from patients who demonstrated a prolonged QTc interval under GA (general anesthesia) and in those who had QTc interval prolongation while receiving RA (regional) or MAC (monitored anesthesia care). Results: Duration of surgery correlated strongly with QTc interval prolongation in patients who were exposed to volatile anesthetics (r=.228, p=.010), but not in patients who received RA/MAC (r=.121, p=.444).

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