alexa Dynamic Change of Serum Proteomics of Occupational Medicamentosalike Dermatitis Induced by Trichloroethylene | OMICS International
ISSN: 2161-0495

Journal of Clinical Toxicology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Dynamic Change of Serum Proteomics of Occupational Medicamentosalike Dermatitis Induced by Trichloroethylene

Ophir Lavon1,2 and Yedidia Bentur2,3*

1Clinical Pharmacology and Toxicology Unit, Carmel Medical Center, Haifa, Israel

2The Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

3Israel Poison Information Center, Rambam Health Care Campus, Haifa, Israel

*Corresponding Author:
Yedidia Bentur
Director, Israel Poison Information Center
Clinical Professor of Medicine and Clinical Toxicology
Rambam Health Care Campus
P.O.B. 9602, Haifa 31096, Israel
Tel: +972-4-7772725
Fax: +972-4-7772092
E-mail: [email protected]

Received: September 29, 2015 Accepted: December 17, 2015 Published: December 21, 2015

Citation: Bentur Y and Lavon O (2015) Acute Inhaled Xylene Poisoning Confirmed by Methylhippuric Acid Urine Test. J Clin Toxicol 5:274. doi: 10.4172/2161-0495.1000274

Copyright: © 2015 Lavon O, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Objective: Extensive researches about biomarkers of Occupational medicamentosa-like dermatitis induced by Trichloroethylene (OMLDT) have been carried out in recent years. But dynamic change of protein biomarkers in serum has rarely been reported. The aim of our study was to explore the dynamic changing law of serum proteins/ polypeptides in different periods of OMLDT, identify potential biomarkers and provide the scientific fundamentals for monitoring the progression of the disease and screening high-risk population.

Study design: We developed an approach in the combination of magnetic beads based weak cation exchange chromatography (MB-WCX), matrix assisted laser desorption ionization time of flight mass spectrometry (MALDITOF- MS) and ClinProTools software. Based on the alternations in the polypeptides fingerprint of serum (PFS), we built diagnostic models of OMLDT, and screened the special proteins/ polypeptides biomarkers and further studied the dynamic changing law of different periods in typical OMLDT patients.

Results: We attained 72 peaks which were statistical content in OMLDT/Normal model, of which 52 peaks were differential peaks. We also obtained 69 significant peaks in OMLDT/TCE Contact model, but the differential peaks were 35. There were 21 specific peaks which were alike among the differential peaks in these two models and the change of their expression level was consistent. Among the 21 specific peaks, we found 4 peaks, which were m/z 410942675065 and 9287Da, changed nearly the same in 3 periods of 4 recurrent patients, and 2 peaks (4109 and 9173 Da) changed consistent in 3 periods of 3 stable patients. Interestingly, m/z 4109 Da appeared in both groups and the expression level was increased with the course of disease. So it may be the special serum biomarker of OMLDT. Conclusion: Overall, the results indicate specific PFS could serve as a useful tool to reflect the dynamic change of proteins/ polypeptides in different periods of OMLDT. And it may provide a new clue for clinical application.

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version