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Dynamic Change of Serum Proteomics of Occupational Medicamentosalike Dermatitis Induced by Trichloroethylene | OMICS International | Abstract
ISSN: 2161-0495

Journal of Clinical Toxicology
Open Access

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Research Article

Dynamic Change of Serum Proteomics of Occupational Medicamentosalike Dermatitis Induced by Trichloroethylene

Ophir Lavon1,2 and Yedidia Bentur2,3*

1Clinical Pharmacology and Toxicology Unit, Carmel Medical Center, Haifa, Israel

2The Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

3Israel Poison Information Center, Rambam Health Care Campus, Haifa, Israel

*Corresponding Author:
Yedidia Bentur
Director, Israel Poison Information Center
Clinical Professor of Medicine and Clinical Toxicology
Rambam Health Care Campus
P.O.B. 9602, Haifa 31096, Israel
Tel: +972-4-7772725
Fax: +972-4-7772092
E-mail: [email protected]

Received: September 29, 2015 Accepted: December 17, 2015 Published: December 21, 2015

Citation: Bentur Y and Lavon O (2015) Acute Inhaled Xylene Poisoning Confirmed by Methylhippuric Acid Urine Test. J Clin Toxicol 5:274. doi: 10.4172/2161-0495.1000274

Copyright: © 2015 Lavon O, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Objective: Extensive researches about biomarkers of Occupational medicamentosa-like dermatitis induced by Trichloroethylene (OMLDT) have been carried out in recent years. But dynamic change of protein biomarkers in serum has rarely been reported. The aim of our study was to explore the dynamic changing law of serum proteins/ polypeptides in different periods of OMLDT, identify potential biomarkers and provide the scientific fundamentals for monitoring the progression of the disease and screening high-risk population.

Study design: We developed an approach in the combination of magnetic beads based weak cation exchange chromatography (MB-WCX), matrix assisted laser desorption ionization time of flight mass spectrometry (MALDITOF- MS) and ClinProTools software. Based on the alternations in the polypeptides fingerprint of serum (PFS), we built diagnostic models of OMLDT, and screened the special proteins/ polypeptides biomarkers and further studied the dynamic changing law of different periods in typical OMLDT patients.

Results: We attained 72 peaks which were statistical content in OMLDT/Normal model, of which 52 peaks were differential peaks. We also obtained 69 significant peaks in OMLDT/TCE Contact model, but the differential peaks were 35. There were 21 specific peaks which were alike among the differential peaks in these two models and the change of their expression level was consistent. Among the 21 specific peaks, we found 4 peaks, which were m/z 410942675065 and 9287Da, changed nearly the same in 3 periods of 4 recurrent patients, and 2 peaks (4109 and 9173 Da) changed consistent in 3 periods of 3 stable patients. Interestingly, m/z 4109 Da appeared in both groups and the expression level was increased with the course of disease. So it may be the special serum biomarker of OMLDT. Conclusion: Overall, the results indicate specific PFS could serve as a useful tool to reflect the dynamic change of proteins/ polypeptides in different periods of OMLDT. And it may provide a new clue for clinical application.