alexa Dyspnea in Post Percutaneous Transluminal Coronary Angi
ISSN: 2329-6607

Cardiovascular Pharmacology: Open Access
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Research Article

Dyspnea in Post Percutaneous Transluminal Coronary Angioplasty (PTCA) Patients on Dual Antiplatelets in a Tertiary Care Hospital in South India

Parvathy Krishnan1, Sharmila Mohan1, Doyce Jom1, Roji Jacob1, Siby Joseph1, Rajesh Thachathodiyl2 and Vikrant Vijan3*

1Department of Pharmacy Practice, Amrita School of Pharmacy, Kerala, India

2Department of Cardiology, Amrita Institute of Medical sciences, Kerala, India

3Department of Cardiology, Amrita Institute of Medical sciences, Amrita Vishwa Vidyapeetham University, AIMS – Kochi Campus, Kerala, India

*Corresponding Author:
Vikrant Vijan
Department of Cardiology
Amrita Institute of Medical sciences
Amrita Vishwa Vidyapeetham University
AIMS–Kochi Campus
Ponekkara P.O., Kochi 682 041, Kerala, India
Tel: +91-9539681750
E-mail: [email protected]

Received date: March 29, 2016; Accepted date: May 26, 2016; Published date: May 30, 2016

Citation: Krishnan P, Mohan S, Jom D, Jacob R, Joseph S, et al. (2016) Dyspnea in Post Percutaneous Transluminal Coronary Angioplasty (PTCA) Patients on Dual Antiplatelets in a Tertiary Care Hospital in South India. Cardiovasc Pharm Open Access 5:182. doi:10.4172/2329-6607.1000182

Copyright: © 2016 Krishnan P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Background: For post Percutaneous Transluminal Coronary Angioplasty for Acute Coronary Syndromes, Dual Antiplatelet Therapy with Aspirin and a P2Y12 receptor inhibitor like Ticagrelor or Clopidogrel is required minimum for a period of 12 months. There are few studies which have shown the incidence of dyspnea in patients receiving antiplatelet therapy. Methods: In this retrospective, single centre, cohort study, patients who underwent PTCA and were on dual antiplatelets were randomly selected from the clopidogrel and ticagrelor group between July 2013 and June 2014. Patient’s relevant data were collected from electronic medical records and cross checked with manually maintained medical records wherever necessary. The study endpoint was incidence of dyspnoea within a follow up period of 9 months. Results: Among the 100 patients started on dual antiplatelet therapy with aspirin and ticagrelor, dyspnea occurred in 10% patients. Ticagrelor was substituted with clopidogrel in 60% cases. In 100 patients on clopidogrel, dyspnea occurred in 5% of patients, but clopidogrel was continued in all cases. Onset of dyspnea in patients on Ticagrelor occurred in 50% of patients in the first month of follow up, 10% cases at 3 months, 30% cases at 6 months and 10% cases at 9 months. But in clopidogrel group dyspnea occurred in 40% cases at 6 months follow up and 60% cases at 9 months. The p value on comparison of dyspnoea among the two groups was found to be 0.283, which was not statistically significant probably due to less sample population. Conclusion: Risk for dyspnoea induced by Ticagrelor was found to be higher than with Clopidogrel in the same ethnic groups when used as dual antiplatelet along with Aspirin. So it may not be a class effect or due to P2Y12 receptor inhibitory action alone.

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