Dysregulation of Nrf2 Signaling in Diabetes: An Opportunity for a Multitarget ApproachBrad P Dieter1,2*
- *Corresponding Author:
- Brad P Dieter
104 W. 5th Ave., Suite 300W
Spokane, WA 99204, USA
E-mail: [email protected]
Received sex: October 31, 2014; Accepted sex: November 27, 2014; Published sex: January 02, 2015
Citation: Dieter BP (2015) Dysregulation of Nrf2 Signaling in Diabetes: An Opportunity for a Multi-target Approach. J Diabetes Metab 6:475 doi:10.4172/2155-6156.1000475
Copyright: © 2015 Dieter BP. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Oxidative stress is a central feature of diabetes and plays a causal role in the pathogenesis of diabetic complications. The nuclear factor-like 2 (Nrf2) transcription factor mediates the induction of antioxidant and cytoprotective genes and is a major regulator of the endogenous antioxidant and detoxification systems. Multiple aspects of the Nrf2 signaling pathway are aberrant in diabetes and simultaneously targeting the dysregulated aspects of the Nrf2 signaling pathway ought to be considered.