alexa E. coli Heat-labile Enterotoxin B Subunit as a Platform for the Delivery of HIV Gag p24 Antigen
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
Open Access

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Research Article

E. coli Heat-labile Enterotoxin B Subunit as a Platform for the Delivery of HIV Gag p24 Antigen

Karmarcha Martin and Toufic O Nashar*
College of Veterinary Medicine, Nursing and Allied Health, Department of Pathobiology, Tuskegee University, Tuskegee, AL 36088, USA
Corresponding Author : Toufic O Nashar
Assistant Professor, College of Veterinary Medicine
Nursing and Allied Health, Department of Pathobiology
Tuskegee University, Tuskegee, AL 36088, USA
Tel: 334-727-8366
Fax: 334-724-4110
E-mail: [email protected]
Received January 29, 2013; Accepted April 16, 2013; Published April 23, 2013
Citation: Martin K, Nashar TO (2013) E. coli Heat-labile Enterotoxin B Subunit as a Platform for the Delivery of HIV Gag p24 Antigen. J Clin Cell Immunol 4:140. doi:10.4172/2155-9899.1000140
Copyright: © 2013 Martin K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Multiple vaccination strategies have been devised against HIV-1 including delivery of HIV moieties in attenuated or replication defective recombinant microbial agents alone or in combination with priming agents in form of soluble proteins or naked DNA. For the priming agents to be effective, adjuvants might be essential in directing the immune response to a desired outcome. E. coli enterotoxin B subunit (LTB) is an effective adjuvant and carrier for other proteins and epitopes. Here we show that conjugation of HIV gag p24 to LTB enhances the T cell response to gag p24 by increasing rate of T cell division compared to other treatments. Because HIV vaccines are likely to be multivalent, we further investigated whether gag p24 inhibits antigen presentation of an unrelated antigen, OVA. Addition of gag p24 to OVA-responsive DO.11.10 cell culture did not have adverse effects on antigen presentation. Interestingly, the presence of LTB in these cultures significantly increased proliferation of DO.11.10 cells. In all, the results suggest the use of LTB to boost immune responses against HIV gag p24 in systemic priming regimens with oral recombinant HIV vaccines.

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