Early Left Ventricular Function Abnormalities in Obstructive Sleep Apnea
|Emil Ivanov Manov1, Nikolay Margaritov Runev1*, Rabhat Ahmed Shabani2, Daniela Georgieva Vasileva2, Radostina Vlaeva Cherneva3, Temenuga Ivanova Donova4, Ognian Borisov Georgiev5 and Daniela Stoichkova Petrova4|
|1Associated Professor, Department of Internal Medicine, Division of Cardiology, Medical University - Sofia, Bulgaria|
|2Department of Internal Medicine, Division of Cardiology, Medical University - Sofia, Bulgaria|
|3Assistant Professor, Department of Internal Medicine, Division of Pulmonary Medicine, Medical University - Sofia, Bulgaria|
|4Professor, Department of Internal Medicine, Chief Division of Cardiology, Medical University - Sofia, Bulgaria|
|5Professor, Head of the Department of Internal Medicine, Division of Pulmonary Medicine, Medical University - Sofia, Bulgaria|
|Corresponding Author :||Nikolay Margaritov Runev
Medical University – Sofia
Department of Internal Medicine
Division of Cardiology
St Georgi Sofiiski str. 1431 Sofia, Bulgaria
Tel: +359 2 9230658
E-mail: [email protected]
|Received May 16, 2014; Accepted June 07, 2014; Published June 14, 2014|
|Citation: Manov EI, Runev NM, Shabani RA, Vasileva DG, Cherneva RV, et al. (2014) Early Left Ventricular Function Abnormalities in Obstructive Sleep Apnea. J Cardiovasc Dis Diagn 2:164. doi: 10.4172/2329-9517.1000164|
|Copyright: © 2014 Runev NM. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
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Introduction: Our aim was to assess by Tissue Doppler Imaging (TDI) the early left ventricular (LV) myocardial function abnormalities in obstructive sleep apnea (OSA).
Methods: Thirty four patients (11 females, 23 males, aged 25-51) with newly diagnosed, nontreated OSA and normal echocardiographic parameters of LV diastolic and systolic function were investigated. The patients with known cardiovascular or respiratory disease were excluded. The LV end-systolic longitudinal strain (LS), peaksystolic longitudinal strain rate (LSR) and isovolumetric acceleration (IVA) of the septal and lateral mitral annulus was evaluated by TDI. Twenty two healthy persons (9 women, 13 men, and aged 23-48) were assessed as controls.
Results: All OSA patients demonstrated significant decrease of the LV end-systolic LS: -15.7 ± 0.42% vs controls: -18.9 ± 0.56% (p<0.01) and LV peak-systolic LSR: 1.72 ± 0.63 s-1 vs 3.19 ± 0.68 s-1, respectively (p<0.001). The IVA was also reduced: the septal mitral annulus: -2.82 ± 0.45 cm/sec in OSA vs -4.03 ± 0.6 cm/sec in healthy subjects (p<0.01) and the lateral mitral annulus: -3.37 ± 0.54 cm/sec in gr. I vs -4.29 ± 0.42 cm/sec in gr. II (p<0.01).
Conclusions: Tissue Doppler Imaging might be a reliable method for detection of early abnormalities in LV function in patients with OSA. Reduction of longitudinal strain, strain rate and isovolumetric acceleration might be present in patients with OSA, even without overt diastolic or systolic LV dysfunction. Further studies with larger sample size are needed.