alexa Early Left Ventricular Function Abnormalities in Obstructive Sleep Apnea
ISSN: 2329-9517

Journal of Cardiovascular Diseases & Diagnosis
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Early Left Ventricular Function Abnormalities in Obstructive Sleep Apnea

Emil Ivanov Manov1, Nikolay Margaritov Runev1*, Rabhat Ahmed Shabani2, Daniela Georgieva Vasileva2, Radostina Vlaeva Cherneva3, Temenuga Ivanova Donova4, Ognian Borisov Georgiev5 and Daniela Stoichkova Petrova4
1Associated Professor, Department of Internal Medicine, Division of Cardiology, Medical University - Sofia, Bulgaria
2Department of Internal Medicine, Division of Cardiology, Medical University - Sofia, Bulgaria
3Assistant Professor, Department of Internal Medicine, Division of Pulmonary Medicine, Medical University - Sofia, Bulgaria
4Professor, Department of Internal Medicine, Chief Division of Cardiology, Medical University - Sofia, Bulgaria
5Professor, Head of the Department of Internal Medicine, Division of Pulmonary Medicine, Medical University - Sofia, Bulgaria
Corresponding Author : Nikolay Margaritov Runev
Medical University – Sofia
Department of Internal Medicine
Division of Cardiology
St Georgi Sofiiski str. 1431 Sofia, Bulgaria
Tel: +359 2 9230658
E-mail: [email protected]
Received May 16, 2014; Accepted June 07, 2014; Published June 14, 2014
Citation: Manov EI, Runev NM, Shabani RA, Vasileva DG, Cherneva RV, et al. (2014) Early Left Ventricular Function Abnormalities in Obstructive Sleep Apnea. J Cardiovasc Dis Diagn 2:164. doi: 10.4172/2329-9517.1000164
Copyright: © 2014 Runev NM. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Related article at
DownloadPubmed DownloadScholar Google


Introduction: Our aim was to assess by Tissue Doppler Imaging (TDI) the early left ventricular (LV) myocardial function abnormalities in obstructive sleep apnea (OSA).

Methods: Thirty four patients (11 females, 23 males, aged 25-51) with newly diagnosed, nontreated OSA and normal echocardiographic parameters of LV diastolic and systolic function were investigated. The patients with known cardiovascular or respiratory disease were excluded. The LV end-systolic longitudinal strain (LS), peaksystolic longitudinal strain rate (LSR) and isovolumetric acceleration (IVA) of the septal and lateral mitral annulus was evaluated by TDI. Twenty two healthy persons (9 women, 13 men, and aged 23-48) were assessed as controls.

Results: All OSA patients demonstrated significant decrease of the LV end-systolic LS: -15.7 ± 0.42% vs controls: -18.9 ± 0.56% (p<0.01) and LV peak-systolic LSR: 1.72 ± 0.63 s-1 vs 3.19 ± 0.68 s-1, respectively (p<0.001). The IVA was also reduced: the septal mitral annulus: -2.82 ± 0.45 cm/sec in OSA vs -4.03 ± 0.6 cm/sec in healthy subjects (p<0.01) and the lateral mitral annulus: -3.37 ± 0.54 cm/sec in gr. I vs -4.29 ± 0.42 cm/sec in gr. II (p<0.01).

Conclusions: Tissue Doppler Imaging might be a reliable method for detection of early abnormalities in LV function in patients with OSA. Reduction of longitudinal strain, strain rate and isovolumetric acceleration might be present in patients with OSA, even without overt diastolic or systolic LV dysfunction. Further studies with larger sample size are needed.


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version