alexa Echinacea Inhibits Adenosine Deaminase Enzyme in Cancerous Human Gastric Tissue | OMICS International | Abstract
ISSN: 2157-2518

Journal of Carcinogenesis & Mutagenesis
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Research Article

Echinacea Inhibits Adenosine Deaminase Enzyme in Cancerous Human Gastric Tissue

Zahide Esra Durak1, Hilmi Kocaoğlu2, Hikmet Can Çubukçu3 and İlker Durak3*
1Turkish Heath Ministry, Institute of Public Health Ankara-Turkey
2Department of Surgical Oncology Ankara University Faculty of Medicine, Ankara-Turkey
3Department of Medical Biochemistry Ankara University Faculty of Medicine, Ankara-Turkey
Corresponding Author : İlker Durak
Department of Medical Biochemistry
Ankara University Faculty of Medicine, Ankara-Turkey
Tel: +903125958268
E-mail: [email protected]
Received: October 28, 2015 Accepted: November 20, 2015 Published: November 25, 2015
Citation: Durak ZE, Kocaoglu H, Çubukçu HC, Durak I (2015) Echinacea Inhibits Adenosine Deaminase Enzyme in Cancerous Human Gastric Tissue. J Carcinog Mutagene 6:246. doi:10.4172/2157-2518.1000246
Copyright: © 2015 Durak I, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Aim: This study aims to investigate the possible effects of aqueous Echinacea (E. Purpurea, whole plant) extract on Adenosine deaminase (ADA) activity in cancerous and non-cancerous human gastric and colon tissues. Materials and Methods: Thirty three cancerous and 33 non-cancerous human gastric tissues, and 25 cancerous and non-cancerous human colon tissues removed by surgical operations were studied. In the samples, adenosine deaminase activities were measured with and without extract incubation. Results: It has been observed that Echinacea extract inhibits ADA enzyme in cancerous gastric tissues significantly. It exerts however no inhibitory effects on the ADA activities in the other tissues. Conclusion: It is proposed that inhibition of ADA enzyme by the Echinacea extract might play part in anti-cancer mechanism of Echinacea in some cancers like gastric cancer.

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