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ISSN-2155-9929

Journal of Molecular Biomarkers & Diagnosis
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  • Research Article   
  • J Mol Biomark Diagn,
  • DOI: 10.4172/2155-9929.S2-032

ECOG or Karnofsky Performance Status to Assess Functionality in Glioblastoma Patients Among Different Observers

Claudia Panciroli1*, Anna Estival2, Giuseppe Lucente3, Jose Maria Velarde2, Roser García3, Laia Vilà2, Sira Domenech4, Salvador Villà5 and Carmen Balañà2
1Clinical Investigation Unit, Institute Català d’Oncologia, University Hospital Germans Trias i Pujol, Spain
2Medical Oncology Service, Institute Català d’Oncologia, University Hospital Germans Trias i Pujol, Spain
3Department of Neuroscience, University Hospital Germans Trias i Pujol, Carretera del Canyet s/n, 08916 Badalona (Barcelona), Spain
4Institute Diagnostic per l’Imatge, University Hospital Germans Trias i Pujol, Carretera del Canyet s/n, Spain
5Radiation Oncology Service, Institute Català d’Oncologia, University Hospital Germans Trias i Pujol, Spain
*Corresponding Author : Claudia Panciroli, Clinical Investigation Unit, Institute Català d’Oncologia, University Hospital Germans Trias i Pujol, Spain, Tel: +34 93 497 8925, Fax: +34 93 497 8950, Email: [email protected], [email protected]

Received Date: Jul 03, 2017 / Accepted Date: Jul 24, 2017 / Published Date: Jul 26, 2017

Abstract

Purpose: Glioblastoma (GB) patients usually have symptoms that affect their functional status, and medical staff, as well as the patients and their caregivers, might have different perceptions about it. The performance status is important to establish a patient’s survival prediction and treatment decisions. This study was aimed to explore whether health care providers, patients, and caregivers have a common perception of patients’ functional statuses and to investigate in further studies whether the functional scales used in oncology clinical practice are objective tools to evaluate brain tumour patients.

Methods: GB patients treated at our Neuro-Oncology Unit were evaluated once using Eastern Cooperative Oncology Group Performance Status (ECOG) and Karnofsky Performance Status (KPS) by a medical oncologist (MO), an independent investigator (II), the patient and the patient’s main caregiver.

Results: Fifty patients were enrolled. Concordance in KPS evaluation among the four observers was low (Fleiss’ Kappa=0.354; p<0.001) and moderate in ECOG one (Fleiss’ K=0.424; p<0.001). Pairing the observers, the concordance between the MO and II was strong (KPS Cohen’s Kappa=0.731; p<0.001, ECOG Cohen’s Kappa=0.741; p=0.001), whereas it was poor between the patient and MO (KPS Cohen’s Kappa=0.250; p=0.007. ECOG Cohen’s Kappa=0.241; p=0.009) and between the caregiver and MO (KPS Cohen’s Kappa=0.350; p<0.001. ECOG Cohen’s Kappa=0.346; p=0.000).

Conclusion: Concordance among the observers was poor or moderate according to the functional scale used. Particularly, caregivers’ perception of the patients’ functional status was frequently worse than that of the professionals.

Keywords: Karnofsky performance status; ECOG performance status; Glioblastoma patients; Caregivers

Citation: Panciroli C, Estival A, Lucente G, Velarde JM, García R, et al. (2017) ECOG or Karnofsky Performance Status to Assess Functionality in Glioblastoma Patients Among Different Observers. J Mol Biomark Diagn S2: 032. Doi: 10.4172/2155-9929.S2-032

Copyright: ©2017 Panciroli C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

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