alexa Ectopic Cardiac Depots, Inflammation and Cardiovascular Disease
ISSN: 2327-5146

General Medicine: Open Access
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Review Article

Ectopic Cardiac Depots, Inflammation and Cardiovascular Disease

Roever L1*, Casella-Filho A2, Dourado PMM2 and Chagas ACP2
1Laboratory of Vascular Biology, Heart Institute (InCor), HCFMUSP- University of São Paulo Medical School, São Paulo, Brazil
2Faculdade de Medicina do ABC, Santo André, Brazil
Corresponding Author : Leonardo S. Roever-Borges
Laboratory of Vascular Biology, Heart Institute (InCor)
University of São Paulo Medical School
Av. Dr. Enéas de Carvalho Aguiar, 44, 05403-900 - São Paulo, Brazil
Tel: 55-11 30695259
Fax: 55-11 30695261
E-mail: [email protected]
Received February 10, 2014; Accepted March 25, 2014; Published April 30, 2014
Citation: Roever L, Casella-Filho A, Dourado PMM, Chagas ACP (2014) Ectopic Cardiac Depots, Inflammation and Cardiovascular Disease. Gen Med (Los Angel) 2:137. doi: 10.4172/2327-5146.1000137
Copyright: © 2014 Roever L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Ectopic fat may cause anatomic and functional abnormalities in adipocyte and adipose tissue, resulting in imbalances in the endocrine and immune system. Adiposopathy may contribute to cardiovascular disease (CVD) through pericardiac and perivascular effects on the myocardium and blood vessels. Adiposopathy may also indirectly contribute to CVD promoting or worsening major CVD risk factors such as type 2 diabetes mellitus, hypertension and dyslipidemia. CVD is the most common cause of mortality among overweight individuals, but the pathophysiologic relationship between adiposity and CVD still is poorly understood, as evidenced by “obesity paradoxes”. Underlying this uncertainty are suggestions that excessive body fat does not always increase the risk of CVD and, in some cases, may actually decrease such risks. This review aims to address the recent aspects of the relationships between ectopic fat, inflammation and CVD.

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