alexa Ectopic G-Csf Production by Malignant Plasma Cells in Patients with Diagnostic Criteria of Chronic Neutrophilic Leukemia
ISSN: 2572-4916

Journal of Bone Research
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Case Report

Ectopic G-Csf Production by Malignant Plasma Cells in Patients with Diagnostic Criteria of Chronic Neutrophilic Leukemia

Rodríguez-Medina C Sevillano-Zamarreño B Gómez-Casares M T*Lemes Castellano A López-Jorge CE Quiroz Cervantes K Campo C Jiménez S Luzardo H de la Iglesia S Molero T

Servicio de Hematología, Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria, Spain

Corresponding Author:
Gómez-Casares MT
Servicio de Hematología. Hospital Universitario de Gran Canaria Doctor Negrín
Las Palmas de Gran Canaria, Spain
E-mail: [email protected]

Received Date: January 30, 2013; Accepted Date: February 27, 2013; Published Date: March 01, 2013

Citation: Rodríguez-Medina C, Sevillano-Zamarreño B, Gómez-Casares MT, Lemes Castellano A, López-Jorge CE, et al. (2013) Ectopic G-Csf Production by Malignant Plasma Cells in Patients with Diagnostic Criteria of Chronic Neutrophilic Leukemia. J Bone Marrow Res 1:111. doi:10.4172/2329-8820.1000111

Copyright: © 2013 Rodríguez-Medina C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Chronic Neutrophilic Leukemia (CNL) is a relatively uncommon myeloproliferative neoplasia. Its diagnosis is based on the exclusion of the possible causes of neutrophilia altogether by the laboratory findings. The ectopic production of G-CSF by pathological plasma cells is well known in the medical literature. We present the case of a 77 year old woman fulfilling the diagnostic criteria of CNL. We verified G-CSF production by her pathological plasma cells using cellular separation techniques and PCR. The purpose of this paper is to communicate another case of the uncommon association between myeloma and neutrophilia, and reinforce the necessity of ruling out the existence of an underlying monoclonal gammopathy when a patient presents with CNL-like symptoms.


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