alexa Effect of Alumina Amount on the Bioactivity of Dense Magnesium Fluorapatite/Alumina Composite in Simulated Body Fluid (SBF) using Taguchi Method | OMICS International
ISSN: 2155-9821

Journal of Bioprocessing & Biotechniques
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Research Article

Effect of Alumina Amount on the Bioactivity of Dense Magnesium Fluorapatite/Alumina Composite in Simulated Body Fluid (SBF) using Taguchi Method

Hejazi MS1,2*, Meratian M1, Ahmadian M1,2 and Fathi MH1,3
1Department of Materials Engineering, Isfahan University of Technology, Isfahan, 84156-83111, Iran
2Biomaterials Research Group, Department of Materials Engineering, Isfahan University of Technology, Isfahan, 8415683111, Iran
3Dental Materials Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Corresponding Author : Hejazi MS
Department of Materials Engineering
Isfahan University of Technology
Isfahan, 84156-83111, Iran
Tel: 983-113-915-73
E-mail: [email protected]
Received March 03, 2015; Accepted Aprile 07, 2015; Published Aprile 13, 2015
Citation: Hejazi MS, Meratian M, Ahmadian M, Fathi MH (2015) Effect of Alumina Amount on the Bioactivity of Dense Magnesium Fluorapatite/Alumina Composite in Simulated Body Fluid (SBF) using Taguchi Method. J Bioprocess Biotech 5:219 doi:10.4172/2155-9821.1000219
Copyright: © 2015 Hejazi MS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and and source are credited.

Abstract

Bioactivity of magnesium fluorapatite is basically affected by the amount of dissolved β-TCP in Simulated Body Fluid (SBF). It was the purpose of the current work to prepare and characterize magnesium fluorapatite with different amounts of alumina, and to investigate the effect of alumina amount on magnesium fluorapatite (MFA) bioactivity and mechanical properties. Magnesium fluorapatite/alumina composite bulk samples with different amounts of alumina were synthesized via mechanochemical activation (by high-energy ball milling process) followed by two-step sintering processes using Taguchi method and analysis of variance (ANOVA). While, variable parameters include: initial temperature (T1), second temperature (T2) and dwell time (t2). In vitro bioactivity evaluation was performed by soaking the prepared samples in Simulated Body Fluid (SBF) for predicted period of times. In order to characterize the samples, identify the formed bone like-apatite, and determine the concentration amount of released ions in the SBF, X-ray diffraction, Fourier transform infrared spectrometry, scanning electron microscopy, inductively-coupled plasma, and spectrometry techniques were utilized. The results indicated that the MFA/alumina composites with various amounts of alumina showed more bioactivity in SBF due to higher dissolution of β-TCP.

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