alexa Effect of Aqueous Crude Extract of Tinospora Crispa on Plasmodium Berghei Induced Liver Damage in Mice
ISSN: 2470-6965

Malaria Control & Elimination
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Effect of Aqueous Crude Extract of Tinospora Crispa on Plasmodium Berghei Induced Liver Damage in Mice

Voravuth Somsak1*, Jutatip Kittitorn1, Sukanya Chachiyo1, Somdet Srichairatanakool2 and Chairat Uthaipibull3

1Department of Clinical Chemistry, Faculty of Medical Technology, Western University, Kanchanaburi 71170, Thailand

2Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand

3Protein-Ligand Engineering and Molecular Biology Laboratory, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Pathumthani 12120, Thailand

*Corresponding Author:
Voravuth Somsak
Department of Clinical Chemistry
Faculty of Medical Technology
Western University, Kanchanaburi 71170, Thailand
Tel: +66898009939
E-mail: [email protected]

Received May 05, 2015; Accepted June 04, 2015; Published June 11, 2015

Citation: Somsak V, Kittitorn J, Chachiyo S, Srichairatanakool S, Uthaipibull C (2015) Effect of Aqueous Crude Extract of Tinospora Crispa on Plasmodium Berghei Induced Liver Damage in Mice. Malar Chemoth Cont Elimination 4:127. doi: 10.4172/2470-6965.1000127

Copyright: © 2015 Somsak VI, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Malaria is still a serious problem with increasing of mortality in children annually. One of major causes of death in malaria, organ damage especially liver, has been observed. Hence, we aimed to investigate hepatoprotective effect of traditional plant, Tinospora crispa during malaria infection using Plasmodium berghei infected mice as in vivo model. Aqueous crude extract of T. crispa was freshly prepared. For in vivo test, groups of ICR mice were intraperitoneally injected with 6×106 parasitized erythrocytes of P. berghei ANKA, and given with the extract at doses 10, 50, and 500 mg/kg twice a day for 4-consecutive days. Aspartate aminotransferase and alanine aminotransferase are measured for liver damage while albumin measurement is for liver function. The results showed that liver damage was observed during malaria infection as indicating by significantly (p<0.05) increase of AST and ALT, and markedly decrease of albumin. Interestingly, T. crispa extract exerted hepatoprotective effect during malaria infection. The highest hepatoprotective activity of the extract was shown at dose of 500 mg/kg. Additionally, there were no any toxics to liver function in normal mice treated with this extract. It can be concluded that aqueous crude extract of T. crispa exerts hepatoprotective effect during P. berghei infection.

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version