Effect of As2O3 and Ginsenoside Rg3 on Inhibiting Angiogenesis in Rabbit Liver VX2 TumorHong Li, Jian Li and Haibo Shao*
The First Affiliated Hospital of China Medical University No.155, North Nanjing Street, Shenyang, P.R China
- *Corresponding Author:
- Haibo Shao
The First Affiliated Hospital of China Medical University
No.155, North Nanjing Street
Shenyang, 110001, P.R China
E-mail: [email protected]
Received date: October 30, 2016; Accepted date: November 09, 2016; Published date: November 14, 2016
Citation: Hong Li, Jian Li, Haibo S (2016) Effect of As2O3 and Ginsenoside Rg3 on Inhibiting Angiogenesis in Rabbit Liver VX2 Tumor. Chemo Open Access 5:219. doi: 10.4172/2167-7700.1000219
Copyright: © 2016 Haibo S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Liver cancer is an aggressive disease with a poor outcome. Here, we implicate the roles of arsenic trioxide (As2O3) and Ginsenoside Rg3 (GRg3) in VX2 carcinoma model of rabbits through CD31 and vascular endothelial growth factor (VEGF). Rabbits VX2 liver cancer models were established, then 24 rabbits were randomly divided into 3 groups with the same number (As2O3, GRg3 and control). Liver function and the levels of VEGF and CD31 were assessed. The tumor weight and levels of VEGF and CD31 in As2O3 and GRg3-treated rabbits were lower than those in controls, while no significant differences between As2O3 and GRg3 groups. There was no significant difference in the liver function among the groups. In conclusion, our findings implicate decreases in the tumor weight and the levels of VEGF and CD31 in the rabbits VX2 liver cancer induced by As2O3 and GRg3, while no significant differences between As2O3 and GRg3. GRg3 might be much more convenient than As2O3 in clinical application.