Effect of Black Tea Extract on Hypoglycemia Induced by Plasmodium berghei ANKA Infection in MiceMuthita Sihabud, Puangphaka Yongthawee, Palatip Chutoam, Suwit Klongthalay and Voravuth Somsak*
Department of Clinical Chemistry, Faculty of Medical Technology, Western University, Kanchanaburi 71170, Thailand
- *Corresponding Author:
- Voravuth Somsak
Department of Clinical Chemistry
Faculty of Medical Technology
Western University, Kanchanaburi 71170, Thailand
E-mail: [email protected]
Received Date: August 08, 2015; Accepted Date: November 16, 2015; Published Date: November 23, 2015
Citation: Sihabud M, Yongthawee P, Chutoam P, Klongthalay S, Somsak V (2015) Effect of Black Tea Extract on Hypoglycemia Induced by Plasmodium berghei ANKA Infection in Mice. Malar Cont Elimination S1-005. doi: 10.4172/2470-6965.1000S1-005
Copyright: © 2015 Sihabud M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Hypoglycemia was found as one of all causes of death in malaria disease and urgently needed to fine new drugs to treat this condition. Hence, the present study was aimed to evaluate the effect of black tea extract on hypoglycemia induced by Plasmodium berghei infection in mice. Aqueous crude extract of black tea was freshly prepared using hot water method and used for efficacy test in vivo. For in vivo test, P. berghei ANKA infected mice were given orally by gavage with 500, 1000, and 2000 mg/kg of black tea extract for 4 consecutive days. Blood glucose levels were then measured. It was found that aqueous crude extract of black tea exerted dose-dependent anti-hypoglycemic activity, especially at a dose of 2000 mg/kg showed the highest activity. Although, pyrimethamine treated group showed significantly (p<0.01) decreasing of blood glucose levels, combination treatment with black tea extract could protect and maintain blood glucose to normal level. It can be concluded that aqueous crude extract of black tea presented anti-hypoglycemic activity against P. berghei infection in mice.