Effect of Body Mass Index on In Vitro Maturation Treatment Outcomes in Women without Polycystic Ovarian Syndrome
|Baris Ata1,2*Ayse Seyhan1Jana Al-Shalaty1Alicia Marzal Escriva1Weon Young Son1Seang Lin Tan1,3|
|1The McGill University Health Centre Reproductive Centre, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada|
|2Assisted Reproduction Unit of the Uludag University School of Medicine, Bursa, Turkey|
|3Montreal Reproductive Centre, Montreal, Quebec, Canada|
|Corresponding Author :||Baris Ata
The McGill University Health Centre Reproductive Centre
Division of Reproductive Endocrinology and Infertility
Department of Obstetrics and Gynecology
McGill University, Montreal, Quebec, Canada
E-mail: [email protected]
|Received April 25, 2013; Accepted June 23, 2013; Published June 25, 2013|
|Citation: Ata B, Seyhan A, Al-Shalaty J, Marzal Escriva A, Son WY, et al. (2013) Effect of Body Mass Index on In vitro Maturation Treatment Outcomes in Women without Polycystic Ovarian Syndrome. J Fertil In Vitro IVF Worldw Reprod Med Genet Stem Cell Biol1:104. doi:10.4172/2375-4508.1000104|
|Copyright: © 2013 Ata B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
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Purpose: Previous studies have suggested that obesity can affect the oocyte yield, embryo quality and
pregnancy rates following IVF. In vitro maturation differs from IVF in several ways including lack of controlled ovarian stimulation, oocyte retrieval when majority are expected to be still immature, and possibly different endometrial environment due to short secretory phase and the lack of exposure to supraphysiologic estrogen levels. Therefore female obesity can affect IVM and IVF cycles differentially. This study aims to assess the effect of female obesity on IVM outcomes in women without polycystic ovarian syndrome.
Methods: Retrospective chart review of 125 women who underwent an IVM cycle during a 5 year period.
Women were divided to four categories based on Body Mass Index (BMI) according to the World Health Organization classification. Procedural and clinical outcomes were compared across different BMI categories. Independent effect of BMI on the odds of achieving a live birth was assessed using a multivariate logistic regression model.
Results: The numbers of cumulus corona complexes, in vivo matured and immature oocytes collected,
metaphase two oocytes available for fertilization, good quality embryos available for transfer and embryos transferred were not statistically significantly different across BMI categories. Likewise, in vitro maturation rate of immature oocytes, fertilization rate, embryo implantation, clinical pregnancy and live birth rates were similar across the groups. BMI category did not have an independent effect after adjusting for possible confounders in the regression model.
Conclusions: BMI does not seem to affect IVM outcomes