alexa Effect of Cholecystectomy on Lipid Profile in Bangladeshi Patients with Cholelithiasis
ISSN: 2167-0943

Journal of Metabolic Syndrome
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Research Article

Effect of Cholecystectomy on Lipid Profile in Bangladeshi Patients with Cholelithiasis

AM Mujibul Haq1, ASM Giasuddin2*, KA Jhuma3 and MAM Choudhury4
1Professor of Medicine, Dept of Medicine, Medical College for Women and Hospital, Chairman, Medical Research Unit (MRU), The Medical and Health Welfare trust ( MHWT), Uttara Model Town, Dhaka, Bangladesh
2Professor of Biochemistry and Immunology, Director, Medical Research Unit (MRU), MHWT, Uttara Model Town, Dhaka, Bangladesh
3Associate Professor of Biochemistry, Department of Biochemistry, Medical College for Women and Hospital, Member Secretory, Medical Research Unit (MRU), MHWT, Uttara Model Town, Dhaka, Bangladesh
4Associate Professor, Department of Surgery, Medical College for Women and Hospital, Uttara Model Town, Dhaka, Bangladesh
*Corresponding Author : Dr ASM Giasuddin
Professor of Biochemistry& Immunology
Director, Medical Research Unit (MRU), MHWT
Uttara Model Town, Dhaka-1230, Bangladesh
Tel: +8801199132135, 144 - 880-2-58953939
E-mail: [email protected]; [email protected]
Received: November 24, 2015; Accepted: December 17, 2015; Published: December 24, 2015
Citation: Giasuddin ASM, Jhuma KA, Choudhury MAM (2015) Effect of Cholecystectomy on Lipid Profile in Bangladeshi Patients with Cholelithiasis. J Metabolic Synd 4:192. doi:10.4172/2167-0943.1000192
Copyright: © 2015 Haq AMM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Objective: As no studies were reported from Bangladesh, the present study was conducted on serum lipid profile, i.e. triglyceride TG), total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C) and high density lipoproteincholesterol (HDL-C) in Bangladeshi patients with cholelithiasis

Patients and methods: A total of 44 adult patients with cholelithiasis and 30 healthy subjects as normal controls (NC) were included in the study. The blood samples were taken from fasting patients at diagnosis before cholecystectomy (Serum-I0), gall bladder bile during cholecystectomy (Bile- I0) and blood sample again after 2-3 months at follow-up (Serum-II0) and from fasting NC subjects. TG, TC, LDL-C and HDL-C were quantitated in serum and bile by standard methods using research kits from reputed companies. The results were compared statistically by ANOVA and Student’s t-test using SPSS propramme

Results: TG level was elevated in Serum- I0 , Bile- I0 and Serum- II0 of patients, being highest in Bile- I0 compared to controls (NC) (p<0.001). TG level was reduced in serum -II0 after cholecystectomy compared to Serum- I0 and Bile- I0, although it remained significantly elevated compared to controls (NC) (p<0.001). TC level was elevated in Bile- I0 compared to Serum- I0 and Serum- II0 (p<0.001). Interestingly, TC was elevated in Serum- II0 after cholecystectomy, although no significant difference was observed between NC and patients Serum- I0 (p=0.835). LDL-C levels in NC, Serum- I0 and Serum- II0 were similar (p=0.126, p=0.121), although Serum-II0 levels was elevated compared to Serum- I0 (p<0.001) and it was much elevated in Bile- I0 (p<0.001). HDL-C levels were similar (p>0.05) among NC, Serum- I0 and Serum- II0, but it was higher in Bile- I0 significantly (p<0.001).

 Conclusion: Alterations in lipid profile in cholelithiasis were significant but complex and cholecystectomy had profound impact suggesting a crucial role of gall bladder. The results were discussed accordingly.

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