Effect of Combined Antiretroviral Therapy on Selected Trace Elements and CD4+T-cell Count in HIV-Positive Persons in an African Setting
- *Corresponding Author:
- Oguntibeju OO
Department of Biomedical Sciences
Cape Peninsula University of Technology Bellville
E-mail: [email protected], [email protected]
Received Date: November 01, 2012; Accepted Date: November 21, 2012; Published Date: November 26, 2012
Citation: Akinola FF, Akinjinmi AA, Oguntibeju OO (2012) Effect of Combined Antiretroviral Therapy on Selected Trace Elements and CD4+T-cell Count in HIVPositive Persons in an African Setting. J AIDS Clinic Res 3:185. doi:10.4172/2155-6113.1000185
Copyright: © 2012 Akinola FF, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
In HIV-infected persons, low serum concentrations of trace elements have been associated with an increased risk of HIV disease progression and mortality. Few data are available to determine whether HAART ameliorates micronutrient deficiencies in HIV-positive persons. In the current study, we investigated the effects of HAART on selected trace elements such as selenium, zinc and copper and on CD4+T-cell count in HIV-positive persons. Fifty HIV-positive individuals with 25 on HAART and 25 who were not on HAART were recruited for the study. Twenty five apparently health persons who were HIV-negative serve as a control group. Serum concentrations of selenium, zinc and copper were estimated by atomic absorption spectrophometric method while CD4+T-cell count was determined by flow cytometric method. Persons on HAART showed significantly (P<0.05) high Zn and CD4+Tcell count compared to PRE-HAART. There was no significant difference in the serum selenium and copper levels between HAART and PRE-HAART persons. In conclusion, HAART significantly improved the immunological status as evidenced by increased CD4+T-cell count and also significantly increased the zinc level in the same group. A large randomized placebo-controlled trial is recommended for future study.