Effect of Combined Garlic Therapy and Comprehensive Rehabilitation Program versus Comprehensive Rehabilitation Program Alone on Control of Clinical Manifestations and Quality of Life of Knee Osteoarthritis Patients
- *Corresponding Author:
- Hussein NA
Assistant Professor of Physical Medicine & Rehabilitation
Faculty of Medicine, Alexandria University
Senior Resident of Physical Medicine & Rehabilitation
Albert Einstein College of medicine, NY, USA
E-mail: [email protected]
Received date: May 8, 2015 Accepted date: May 28, 2015 Published date: May 31, 2015
Citation: Hussein NA, Sharara GM (2015) Effect of Combined Garlic Therapy and Comprehensive Rehabilitation Program versus Comprehensive Rehabilitation Program Alone on Control of Clinical Manifestations and Quality of Life of Knee Osteoarthritis Patients. Int J Phys Med Rehabil 3:282. doi:10.4172/2329-9096.1000282
Copyright: © 2015, Hussein NA et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objective: To compare the effect of comprehensive rehabilitation program versus combined garlic therapy and comprehensive rehabilitation program in controlling the clinical manifestations and quality of life in patients with knee osteoarthritis
Design: Randomized clinical trial
Setting: Outpatient setting
Participants: 43 patients with knee osteoarthritis randomized to group I (comprehensive rehabilitation) (n=15) and group II (combined garlic therapy and comprehensive rehabilitation) (n=28).
Intervention: All patients had diet modification, electrotherapy, resistance and flexibility exercises for legs 3 times weekly for 8 weeks. Group II received garlic capsules 900mg daily with breakfast for 8 weeks.
Main Outcome measures: knee pain by visual analogue scale (VAS), Stanford health assessment questionnaire (HAQ), one repetition maximum (1RM) for quadriceps, body mass index (BMI), synovial fluid level of interleukin1β, interleukin 6, tumor necrosis factor Î¬ and selenium.
Results: BMI significantly decreased in both groups (Ρ‹.05) without significant difference between groups. Knee pain significantly decreased in group II mean ± standard deviation (-51.77 ± 11.17%) more than in group I (-22.92 ± 5.31%) (Ρ=.00001). 1 RM significantly increased in group II (105.10± 65.90%) more than in group I (64.78 ± 54.77%) (Ρ=.01986). Percent change of HAQ was more in group II (-36.56 ± 12.2) than in group I (-16.42 ± 14.10) (Ρ=.00004). Synovial selenium significantly increased only in group II (213.19 ± 28.26%) (Ρ=.00001). Synovial inflammatory mediators significantly reduced only in group II (interleukin1β (-89.67% ± 3.73) (Ρ=.00001), interleukin 6 (-92.98% ± 5.02) (Ρ=.00001), tumor necrosis factor Î¬ (-83.20% ± 8.52) (Ρ=.00001).
Conclusion: Garlic improves rehabilitation outcome of knee osteoarthritis