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ISSN: 2155-9880

Journal of Clinical & Experimental Cardiology
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  • Research Article   
  • J Clin Exp Cardiolog 2017, Vol 8(12): 560
  • DOI: 10.4172/2155-9880.1000560

Effect of Diabetes on Myocardial Infarct and No Reflow Size in an Experimental Rat Model and Clinical Trial

Wangde Dai1,2*, Robert A Kloner1,2, Jianru Shi1,2, Juan Carreno1, Serge Korjian3, Yazan Daaboul3, Michael C Gibson3, Muriel Bouly4 and Marc Isabelle5
1HMRI Cardiovascular Research Institute, Huntington Medical Research Institutes, , 10 Pico Street, Pasadena, CA 91105, USA
2Division of Cardiovascular Medicine of the Keck School of Medicine, University of Southern California, Los Angeles, California 90017-2395, USA
3Department of Medicine, PERFUSE Study Group, Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, , Boston, Massachusetts, USA
4Institut de Recherches Internationale Servier, , 50 rue Carnot, 92284, Suresnes Cedex, France
5Institut de Recherches Servier (IdRS), , 3, rue de la République, 92150, Suresnes Cedex, France
*Corresponding Author : Wangde Dai, HMRI Cardiovascular Research Institute, Huntington Medical Research Institutes, 10 Pico Street, Pasadena, California 91105, USA, Tel: 626-397-5812, Email: [email protected]

Received Date: Dec 07, 2017 / Accepted Date: Dec 12, 2017 / Published Date: Dec 15, 2017

Abstract

Background: We determined the effect of diabetes on no reflow and myocardial infarct sizes in both an experimental rat model of diabetes and a contemporary trial of subjects with STEMI.

Methods: Adult Zucker Diabetic Fatty (ZDF) and Sprague Dawley (SD) rats (n=15 each group) were subjected to left coronary artery occlusion for 30 min followed by 3 h of reperfusion. In the clinical trial, the myocardial infarct (MI) size and the zone of microvascular obstruction were assessed in 258 non-diabetic MI patient and 34 diabetic MI patients.

Results: There was no difference in infarct size (median) in ZDF rats (49.9%) versus SD rats (59.6%; p=0.32); there was no difference in no-reflow size (mean ± SEM) in ZDF rats (32.5 ± 3.5%) versus SD rats (32.7 ± 4.3%; p=0.97). In the clinical study, CK-MB and Troponin I area under the curve at 72 h were comparable between the 2 groups. Infarct size by MRI on day 4 was 37.9 ± 1.8 ml in 216 non-diabetic patients and 34.8 ± 4.7 ml in 27 diabetic patients (p=0.559). The ratio of micro vascular obstruction on day 4 on the MRI was 0.179 ± 0.018 of the left ventricle in 200 non-diabetic patients and 0.220 ± 0.060 of the left ventricle in 23 diabetic patients.

Conclusions: Both animal and clinical studies demonstrated no evidence for a larger infarct size, or larger area of no reflow in the diabetic compared to non-diabetic conditions.

Keywords: Diabetes; Myocardial infarction; No-reflow

Citation: Dai W, Kloner RA, Shi J, Carreno J, Korjian S, et al. (2017) Effect of Diabetes on Myocardial Infarct and No Reflow Size in an Experimental Rat Model and Clinical Trial. J Clin Exp Cardiolog 8: 560. Doi: 10.4172/2155-9880.1000560

Copyright: ©2017 Dai W, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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