alexa EFFECT OF DICLOFENAC SODIUM ANGIOGENESIS USING CHORIOALLANTOIC MEMBRANE (CAM) ASSAY | OMICS International | Abstract
ISSN: 1920-4159

Journal of Applied Pharmacy
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

EFFECT OF DICLOFENAC SODIUM ANGIOGENESIS USING CHORIOALLANTOIC MEMBRANE (CAM) ASSAY

Abstract

Angiogenesis, the formation of new blood vessels, is a hallmark of almost all neoplastic and non-neoplastic degenerative diseases. This process supports normal physiology as well as it contributes in progression of different diseases. Angiogenesis contributes in growth of tumor and progressive arthritis. Inflammatory mediators are involved in cancer induced angiogenic process. Cyclo-oxygenases promote these mediators which help in cell migration and endothelial cell spreading. To explore the role of diclofenac sodium in angiogenesis we have used in vitro Chorioallantoic membrane assay. A novel image probing system SPIP (scanning probe image processor) was utilized for assessment and quantification of structural changes in CAMs. Fourteen parameters of 3D surface roughness were also evaluated for quantification. Application of diclofenac sodium on Chorioallantoic membrane at day six of incubation (0.7% concentration of diclofenac sodium) showed anti-angiogenic effect. Results showed marked changes in architecture of CAMs, thinning of primary, secondary and tertiary blood vessels, reduction in surface roughness parameters, increase in kurtosis of surface, and decrease in Abbott curve. The substantial quantities of diclofenac sodium use locally may exhibit anti-angiogenic activity in the same manner those seen in in-vitro and explain its clinical efficacy.

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]sonline.com

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7