Effect of Different Solvents in Solvent Casting of Porous caffolds in Biomedical and Tissue Engineering Applications
- Corresponding Author:
- Smita Mohanty
Laboratory for Advanced Research in Polymeric Materials (LARPM)
Bhubaneswar, Odisha, India
Tel: 0674 2742852,2740173
Fax: 0674 2740463
Email: [email protected]
Received date: July25, 2014; Accepted date: October 29, 2014; Published date: November 3, 2014
Citation: Choudhury M, Mohanty S, Nayak S (2015) Effect of Different Solvents in Solvent Casting of Porous Pla Scaffolds – In Biomedical and Tissue Engineering Applications. J Tissue Sci Eng 6:142. doi:10.4172/2157-7552.1000142
Copyright: © 2015 Choudhury M et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
In the present investigation, PLA porous scaffolds was fabricated using NaCl as porogen in three different solvents i.e. 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP), dichloromethane (DCM) and chloroform (CF) respectively, by solvent casting particulate leaching method. The morphology, structure and thermal behaviour of the PLA scaffolds for porosity measurement were evaluated using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR); thermo gravimetric analysis (TGA) and differential scanning calorimetry (DSC). The developed porous scaffolds were further characterized for porosity measurement, solvent uptake property and water absorption capacity at different temperatures. PLA/ CF scaffold depicted higher porosity factor (93%) along with enhanced water uptake capacity (220%) as against PLA/ HFIP scaffold (75%). However PLA/ DCM scaffolds illustrated more thermal stability as compared with PLA/ HFIP and PLA/ CF scaffolds.