alexa Effect of Erytherina senegalensis on the oestrogen leve
ISSN: 2161-0940

Anatomy & Physiology: Current Research
Open Access

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Research Article

Effect of Erytherina senegalensis on the oestrogen level and histology of ovary of an adult female albino wistar rats

Nnama TN*, Ezejindu DN, Ilodibe CS and Nwogueze BC

Nnamdi Azikiwe University of Nnewi, Anambra, Nigeria

*Corresponding Author:
Nnama TN
Nnamdi Azikiwe University of Nnewi, Anambra, Nigeria
Tel: + 234 808 730 9304
E-mail: [email protected]

Received date: June 11, 2017; Accepted date: June 20, 2017; Published date: June 27, 2017

Citation: Nnama TN, Ezejindu DN, Ilodibe CS, Nwogueze BC (2017) Effect of Erytherina senegalensis on the oestrogen level and histology of ovary of an adult female albino wistar rats. Anat Physiol 7:269. doi:10.4172/2161-0940.1000269

Copyright: © 2017 Nnama TN, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Erytherina senegalensis are used in soups administered after delivery, also in Nigeria; it is given to women during labour to ease pain, for treatment of malaria, gastrointestinal disorders, fever, dizziness, secondary sterility, diarrhoea, jaundice, nose bleeding, pain, bronchial infection, coughs, throat inflammation and administered for venereal diseases. In view of its usage, the study sought to investigate the effect of Erytherina senegalensis leaf extract on the oestrogen level and the histology of the ovary of albino wistar rat. Fresh mature leaf samples of E. senegalensis were collected, ethanolic extract was prepared and the effect of sub-chronic oral administration of the leaf extract of E. senegalensis was studied using twenty-five female albino wistar rats. The oral administration of the leaf extract was done three times per week, for 60 days at doses of 2000 mg/kg for group 1, 4000 mg/kg for group 2, 6000 mg/kg for group 3, 8000 mg/kg body weight for group 4 and group 5 is the control group, received distilled water and food alone. The rats were anaesthetised by chloroform in a close jar and blood samples were for hormonal test, experimental rats were sacrificed by cervical dislocation and the ovary harvested. There was a dose dependent increase in the level of oestrogen across the groups and there was no significant alteration on the histology of the ovary across the groups. Oestrogen level and histology architecture reveals the leaf extract didn’t show any sign of toxicity on the hormone and organ of the study, this may suggest that the extract may be used as female hormonal supplement and may not be toxic when administered orally.

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