Effect of Ethanolic Extract of Hyphaen thebaica (L) Seed on Some Haematological, Biochemical and Histological Features of Albino Rats
Received Date: Jan 16, 2018 / Accepted Date: Feb 15, 2018 / Published Date: Feb 21, 2018
It is well known that many diseases throughout the world are well treated with medicinal plants which have great protective and therapeutic effects. The effect of crude ethanolic extract of Hyphaene thebaica (L) Mart (HT) on some hematologicalindices and some biochemical parameters in normal albino rats in addition to the histological studies on liver and kidney tissues of these rats were investigated.
Thirty two normal white male albino rats were divided into four groups of eight rats/each group. Group one served as the control group, group 2, 3 and 4 served as the test groups for the crude ethanolic extract of HT seeds to which oral intubation of 100 mg/Kg, 200 mg/Kg and 400 mg/Kg dosages of the extracts were administered, respectively. All the rats were fed with normal diet and water ad-libitum for 21 days then after then, all groups were sacrificed, two blood samples were collected for haematological and biochemical parameters. Specimens from liver and kidney were collected for histopathological examination.
Group (3; 200 mg/Kg) and group (4; 400 mg/Kg) revealed a significant increase (P≤ 0.05) increase in total WBCs, total RBCs, and haemoglobin concentration compared with the control. However, significant decrease (P ≤ 0.05) was observed in the level of cholesterol and triglycerides after treating with 400 mg/Kg dose only when compared with the control. There was no significant change in platelets count, liver functions (alanine transaminase (ALT), asparatate transaminase (AST), alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (GGT), Albumin and total protein) and kidney functions (urea and creatinine).Histopathological results of taken liver and kidney tissues revealed no significant changes when compared with the control group.
The crude ethanolic extracts of HT seeds hashypolipidimic effect and may be able to boost immune system.
Keywords: Seeds; Hyphaene thebaica; Albino rats; Haematological studies; Biochemical studies; liver histopathology
Citation: Ali SM, Abu-Almaaty AH, Abbas OA, Hassan MK (2018) Effect of Ethanolic Extract of Hyphaen thebaica (L) Seed on Some Haematological, Biochemical and Histological Features of Albino Rats. J Cytol Histol 9: 494. Doi: 10.4172/2157-7099.1000494
Copyright: ©2018 Ali SM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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