alexa Effect of Exercise on Pancreatic Islets in Zucker Diabetic Fatty Rats
ISSN: 2155-6156

Journal of Diabetes & Metabolism
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Effect of Exercise on Pancreatic Islets in Zucker Diabetic Fatty Rats

Sonia Rawal1, Han-Hung Huang2, Lesya Novikova1, Tyler Hamedi1, Irina V Smirnova1 and Lisa Stehno-Bittel1*

1Department of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, Kansas, USA

2Angelo State University, San Angelo, Texas, USA

*Corresponding Author:
Lisa Stehno-Bittel
Department of Physical Therapy and Rehabilitation Science
MS 2002, University of Kansas Medical Center
Kansas City, KS 66160, USA
Tel: (913)-5886733
Fax: (913)-5884568
E-mail: [email protected]

Received date June 10, 2013; Accepted date July 09, 2013; Published date July 14, 2013

Citation: Rawal S, Huang HH, Novikova L, Hamedi T, Smirnova IV, et al. (2013) Effect of Exercise on Pancreatic Islets in Zucker Diabetic Fatty Rats. J Diabetes Metab S10:007. doi:10.4172/2155-6156.S10-007

Copyright: © 2013 Rawal S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Exercise and physical activity improve the glycemic control in people with type 2 diabetes (T2D). It is known that activity improves muscle utilization of glucose, and that exercise can spare islets if initiated prior to the onset of diabetes. However, any effect of exercise on pancreatic islet function after the diagnosis of overt diabetes is unknown. The aim of the study was to investigate the effects of exercise training on pancreatic islets in a rodent model of overt T2D. 12-week old male Zucker Diabetic Fatty (ZDF) rats and control lean rats were divided into 4 groups: sedentary control exercised control, sedentary diabetic and exercised diabetic. Exercised rats were trained with moderate intensity running on a treadmill for 7 weeks. Assessment of plasma insulin levels, islet cell composition (relative proportion of α, β and δ cells), islet density, insulin content and islet core diameter was conducted at the end of the study. Diabetes in ZDF rats lead to high HbA1c and BGLs, which was not reversed by exercise. Diabetes caused destruction of the islet structure and significant loss of β-cells, with an increased proportion of α- and δ-cells. Exercise improved islets morphology in the diabetic group, while islet density and islet cell composition were not affected by exercise. Increased insulin immunostaining of the pancreatic islets was identified in the diabetic animals after exercise. Although exercise did not affect the diabetes-induced decrease in the proportion of islet β cells, there appeared to be an improvement in the islet architecture and in β-cell insulin content.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

clinical_bioch[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords