Effect of Eyewash Solution (Commercial Washing Solution) on the Corneal Epithelium: Adverse Effects of Benzalkonium Chloride on the Eye Surface
- *Corresponding Author:
- Hiroshi Fujishima
Department of Ophthalmology
Tsurumi University School of Dental Medicine
2-1-3 Tsurumi, Tsurumi-ku
Yokohama, Kanagawa 230-8501, Japan
E-mail: [email protected]
Received date: May 09, 2016; Accepted date: June 24, 2016; Published date: June 28, 2016
Citation: Iwashita M, Murato D, Yano H, Santo Y, Nozaki M, et al. (2016) Effect of Eyewash Solution (Commercial Washing Solution) on the Corneal Epithelium: Adverse Effects of Benzalkonium Chloride on the Eye Surface. J Clin Exp Ophthalmol 7:571. doi:10.4172/2155-9570.1000571
Copyright: © 2016 Iwashita M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Purpose: In recent years, there has been an increasing interest in eye washing in healthy individuals due to pollinosis and an increase in the number of people wearing contact lenses. Previously, commercial eyewash solutions contained a preservative (benzalkonium chloride [BAK]) that was shown to be associated with epithelium disorders. However, currently, a reduction in corneal epithelium disorders is assumed to be due to the popularization of eyewash solutions lacking BAK (over-the counter drugs). Methods: We performed a comparative study between current eyewash solutions and those utilized in the past, and examined the effects of BAK on the cornea in both rabbit and human eyes. Results: Eyewash solutions containing BAK were associated with corneal epithelium disorders and collapse of the mucin layer in the cornea. However, eyewash solutions lacking BAK were not associated with corneal epithelium disorders and did not affect the mucin layer. Conclusion: The study highlights the adverse effects of a preservative and the safety of eyewash solutions not containing a preservative.