Effect of Fluoxetine on Motor Recovery after Acute Haemorrhagic Stroke: A Randomized TrialIrfan Ahmad Shah1*, Ravouf P Asimi1, Yuman Kawoos2, Mushtaq A Wani1, Maqbool A Wani1 and Mansoor A Dar2
- *Corresponding Author:
- Senior resident hostel, SKIMS
Soura, Srinagar, India
E-mail: [email protected]
Received date: February 26, 2016 Accepted date: March 29, 2016 Published date: April 05, 2016
Citation: Shah IA, Asimi RP, Kawoos Y, Wani MA, Wani MA, et al. (2016) Effect of Fluoxetine on Motor Recovery after Acute Haemorrhagic Stroke: A Randomized Trial. J Neurol Neurophysiol 7:364. doi:10.4172/2155-9562.1000364
Copyright: © 2016 Shah IA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: A few clinical trials have suggested that selective serotonin reuptake inhibitors (SSRI’s) enhance motor recovery after stroke but no study has been done in haemorhagic stroke patients. We therefore aimed to investigate whether fluoxetine, an SSRI would enhance motor recovery in patients of haemorrrhagic stroke.
Methods: Patients who had haemorrhagic stroke with hemiplegia or hemiparesis and were aged between 18 years and 80 years were included in this double-blind, placebo-controlled trial. Patients were randomly assigned, in a 1:1 ratio to fluoxetine (20 mg/d, orally) or placebo for 3 months starting 5-10 days after the onset of stroke. All patients also had routine physiotherapy. The primary outcome measure was the change on the FMMS between day 0 and day 90 after the start of the study drug. Results: A total of 89 patients were assigned to fluoxetine (n=45) or placebo (n=44), group, and 84 were finally included in the analysis (42 vs 42) after 5 patients lost to follow up. Mean FMMS score improved significantly greater at day 90 in the fluoxetine group (mean 35.64 points) than in the placebo group (23.60 points; p =0.001).
Conclusion: Use of fluoxetine in patients of haemorrhagic stroke in early post stroke period added to physiotherapy increased recovery in motor deficits at 3 months.