Effect of GXM (Glucuronoxylomannan) on the Inflammatory Response in Lung Infection Caused by Cryptococcus neoformans (Serotype A) in Immunodeficient Murine Model (BALB/c-SCID)Eriques Gonçalves Silva1*, Sandra Marilia de Souza Silva2, Claudete Rodrigues Paula3 and Luciana da Silva Ruiz4
- *Corresponding Author:
- Eriques Gonçalves da Silva
Jayme Daige Filho, 662-3° Andar
Guarujá 11410-410, São Paulo, Brazil
E-mail: [email protected]
Received date: August 12, 2016; Accepted date: November 25, 2016; Published date: December 01, 2016
Citation: Silva EG, Silva SM, Paula CR, Ruiz L (2016) Effect of GXM (Glucuronoxylomannan) on the Inflammatory Response in Lung Infection Caused by Cryptococcus neoformans (Serotype A) in Immunodeficient Murine Model (BALB/c-SCID). J Med Microb Diagn 5:244. doi:10.4172/2161-0703.1000244
Copyright: © 2016 Silva EG, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
GXM (glucuronoxylomannan) is the major component surrounding the capsule of Cryptococcus neoformans having multiple biological functions, one of them and most important, the reduction in production of inflammatory cytokines. They were evaluated in this study the correlation of the production GXM with TNF, IL-6, IL-10, as well, as survival in murine model (BALB-c) and severe combined immunodeficiency (SCID). The animals were infected intravenously with 0.1 ml of a suspension containing 3.0 × 106 model, BALB-c compared to the model. The high production GXM as well as the induction of viable cells of C. neoformans. There was an increase in the production of GXM, as well as a decrease in survival in (SCID) a severe inflammatory response in this model may be due to a compromised immune system.