alexa Effect of High Dose Thiamine Therapy on Risk Factors in Type 2 Diabetics | OMICS International | Abstract
ISSN: 2155-6156

Journal of Diabetes & Metabolism
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Effect of High Dose Thiamine Therapy on Risk Factors in Type 2 Diabetics

Saadia Shahzad Alam1, Samreen Riaz2* and Waheed Akhtar M3

1Department of Pharmacology, Federal Postgraduate Medical Institute, Lahore, Pakistan

2University of the Punjab, Lahore, Pakistan

3School of Biological Sciences University of the Punjab, Lahore, Pakistan

*Corresponding Author:
Samreen Riaz
University College London, UK
E-mail: [email protected]

Received date: October 13, 2012; Accepted date: November 24, 2012; Published date: November 30, 2012

Citation: Alam SS, Riaz S, Waheed Akhtar M (2012) Effect of High Dose Thiamine Therapy on Risk Factors in Type 2 Diabetics. J Diabetes Metab 3:233. doi: 10.4172/2155-6156.1000233

Copyright: © 2012 Alam SS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Traditional and more recently, a host of nontraditional risk factors of type 2 diabetes mellitus have adopted significance as promoters of the pathologies associated with this disease. High dose Vitamin B1 (thiamine) has been found at preclinical level to play an ameliorative role through a number of intracellular metabolic pathways. In order to demonstrate this clinically, pioneering research on the effect of high dose thiamine on associated markers of biochemical dysfunction, incipient diabetic nephropathy, hemostasis (plasminogen activation inhibitor/PAI-1), oxidative stress (plasma thiols) and second messenger signaling (protein kinase C/ PKC ) was conducted.

Subjects and methods: Type 2 diabetics were enrolled in randomized, double blind placebo controlled clinical trial for 6 months. Patients were divided into two groups and administered 300 mg/day thiamine or placebo for 3 months, followed by a 2 month washout period. Normal healthy controls participated for baseline estimations only. Plasma and urinary thiamine levels, microalbuminuria, PAI-1, oxidative stress marker plasma thiols were estimated. The messenger signaling PKC profile was determined in normal controls and in type 2 diabetics.

Results: Lower plasma thiamine concentration of diabetic patients was observed as compared to normal subjects. Thiamine treatment increased thiamine concentration and urinary thiamine excretion and reduced significantly microalbuminuria and glycated hemoglobin. Type 2 diabetics had significantly higher PAI-1 and PKC levels as compared to normal controls. Following 3 months thiamine therapy, PAI-1 remained unchanged, while levels of PKC were reduced significantly in thiamine treated diabetics and lowered after discontinuing the drug. While in placebo group significant increase in PKC levels persisted during the whole period. Oxidative stress marker, plasma thiols was reduced significantly in diabetics versus normal controls with no change occurring following thiamine or placebo therapy.

Conclusion: Thiamine therapy significantly improved micoalbuminuria, glycated hemoglobin, thiamine status and decreased PKC levels with no significant impact on oxidative stress and fibrinolysis profile.

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version