Effect of Hydroxychloroquine on Type 2 Diabetes Mellitus Unresponsive to More Than Two Oral Antidiabetic Agents
Received Date: Sep 20, 2017 / Accepted Date: Oct 27, 2017 / Published Date: Oct 31, 2017
Background and aims: The aims of the present study were to evaluate the effectiveness of Hydroxychloroquine as an add-on therapy to metformin and Sulfonylurea (SU) in reducing glycosylated hemoglobin (HbA1c) to achieve therapeutic goals. Methods: In this open-labelled comparative observational study, two groups of 100 uncontrolled Type 2 Diabetes Mellitus (T2DM) patients in each were studied for 24 Weeks (6 months). Both the groups were divided into patients who were on triple drug combinations. One group receiving Metformin,Glimepiride and Tenelegliptin and the other group received Metformin,Glimepiride and Hydroxychloroquine. In each group fasting blood sugar and as postprandial blood sugar were tested at the start of the study and at 4 weeks intervals. HbA1c was tested at the beginning of study, at 12 Weeks (3 months) and at the end of 24 weeks (6 months). Results: After 24 weeks of treatment, there was significant fall in fasting, as well as postprandial blood sugar and HbA1c levels in patients containing Hydroxychloroquinine in comparison to Tenelegliptin. Conclusions: Hydroxychloroquine significantly improves glycaemic control in patients with T2DM when prescribed as an add-on therapy in addition to two other commonly prescribed antidiabetic drugs such as Glimipirde and metformin combination, and even its efficacy to reduce blood sugar is compairable to newer generation drugs like Teneligliptin. Hydroxychloroquine may be considering as an ideal add-on third drug therapy in the treatment of uncontrolled T2 DM patients.
Keywords: Glycemic control; Hydroxychloroquine; Type 2 diabetes mellitus
Citation: Jagnani VK, Bhattacharya NR, Satpathy SC, Hasda GC, Chakraborty S (2017) Effect of Hydroxychloroquine on Type 2 Diabetes Mellitus Unresponsive to More Than Two Oral Antidiabetic Agents . J Diabetes Metab 8: 771. Doi: 10.4172/2155-6156.1000771
Copyright: © 2017 Jagnani VK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Select your language of interest to view the total content in your interested language
Share This Article
- Total views: 2725
- [From(publication date): 0-2017 - Jun 16, 2019]
- Breakdown by view type
- HTML page views: 2552
- PDF downloads: 173