alexa Effect of Hydroxychloroquine on Type 2 Diabetes Mellitus Unresponsive to More Than Two Oral Antidiabetic Agents | OMICS International| Abstract
ISSN: 2155-6156

Journal of Diabetes & Metabolism
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
  • Research   
  • J Diabetes Metab 2017, Vol 8(10): 771
  • DOI: 10.4172/2155-6156.1000771

Effect of Hydroxychloroquine on Type 2 Diabetes Mellitus Unresponsive to More Than Two Oral Antidiabetic Agents

Jagnani VK1*, Bhattacharya NR2, Satpathy SC3, Hasda GC4 and Sourav Chakraborty5
1Diabetologist, Agrasen Hridayalaya Research Foundation, , Ranchi, Jharkhand, India
2Diabetologist, DHLT Clinic and Research Centre, , Kolkata, West Bengal, India
3Diabetologist, Subhash Diabetic Research Institute, , Kolkata, West Bengal, India
4Diabetologist, North Point Diabetic Clinic and Research Centre, , Kolkata, West Bengal, India
5Diabetologist, WDTT Diabetic Clinic, , Kolkata, West Bengal, India
*Corresponding Author : Jagnani VK, Diabetologist, Agrasen Hridayalaya Research Foundation, Ranchi, Jharkhand, India, Tel: +91-9883006599, Email: [email protected]

Received Date: Sep 20, 2017 / Accepted Date: Oct 27, 2017 / Published Date: Oct 31, 2017

Abstract

Background and aims: The aims of the present study were to evaluate the effectiveness of Hydroxychloroquine as an add-on therapy to metformin and Sulfonylurea (SU) in reducing glycosylated hemoglobin (HbA1c) to achieve therapeutic goals. Methods: In this open-labelled comparative observational study, two groups of 100 uncontrolled Type 2 Diabetes Mellitus (T2DM) patients in each were studied for 24 Weeks (6 months). Both the groups were divided into patients who were on triple drug combinations. One group receiving Metformin,Glimepiride and Tenelegliptin and the other group received Metformin,Glimepiride and Hydroxychloroquine. In each group fasting blood sugar and as postprandial blood sugar were tested at the start of the study and at 4 weeks intervals. HbA1c was tested at the beginning of study, at 12 Weeks (3 months) and at the end of 24 weeks (6 months). Results: After 24 weeks of treatment, there was significant fall in fasting, as well as postprandial blood sugar and HbA1c levels in patients containing Hydroxychloroquinine in comparison to Tenelegliptin. Conclusions: Hydroxychloroquine significantly improves glycaemic control in patients with T2DM when prescribed as an add-on therapy in addition to two other commonly prescribed antidiabetic drugs such as Glimipirde and metformin combination, and even its efficacy to reduce blood sugar is compairable to newer generation drugs like Teneligliptin. Hydroxychloroquine may be considering as an ideal add-on third drug therapy in the treatment of uncontrolled T2 DM patients.

Keywords: Glycemic control; Hydroxychloroquine; Type 2 diabetes mellitus

Citation: Jagnani VK, Bhattacharya NR, Satpathy SC, Hasda GC, Chakraborty S (2017) Effect of Hydroxychloroquine on Type 2 Diabetes Mellitus Unresponsive to More Than Two Oral Antidiabetic Agents . J Diabetes Metab 8: 771. Doi: 10.4172/2155-6156.1000771

Copyright: © 2017 Jagnani VK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Leave Your Message 24x7
Top