Effect of Insulin Resistance in Chronic Kidney DiseaseFrankel AH1* and Kazempour-Ardebili S2
- *Corresponding Author:
- Andrew H Frankel
Imperial College Kidney and Transplant Institute
Imperial College London
Tel: +98 912 188 1096
E-mail: [email protected]
Received date: September 23 2015; Accepted date: October 12, 2016; Published date: October 31, 2016
Citation: Frankel AH, Kazempour-Ardebili S (2016) Effect of Insulin Resistance in Chronic Kidney Disease. Endocrinol Metab Syndr 5:255. doi:10.4172/2161-1017.1000255
Copyright: © 2016 Frankel AH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Insulin resistance accompanies many well-established cardiovascular risk factors, such as obesity, hypertension, dyslipidaemia and type 2 diabetes. Since cardiovascular disease (CVD) is the leading cause of death in patients with end stage renal disease (ESRD), insulin resistance is thought to play a role in the morbidity and mortality associated with ESRD. This paper reviews the available information on insulin resistance in patients with impaired kidney function as well as those on renal replacement therapy in the form of maintenance hemodialysis. Potential mechanisms for the dynamic changes in insulin resistance, which occur through the different stages of kidney disease, are also discussed. We hypothesize that stabilizing insulin sensitivity may have a positive effect on improving outcome in ESRD subjects.