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ISSN: 2161-1017

Endocrinology & Metabolic Syndrome
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Review Article

Effect of Insulin Resistance in Chronic Kidney Disease

Frankel AH1* and Kazempour-Ardebili S2

1Imperial College Kidney and Transplant Institute, Hammersmith Hospital, Imperial College London, London, UK

2Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

*Corresponding Author:
Andrew H Frankel
Imperial College Kidney and Transplant Institute
Hammersmith Hospital
Imperial College London
London, UK
Tel: +98 912 188 1096
E-mail: [email protected]

Received date: September 23 2015; Accepted date: October 12, 2016; Published date: October 31, 2016

Citation: Frankel AH, Kazempour-Ardebili S (2016) Effect of Insulin Resistance in Chronic Kidney Disease. Endocrinol Metab Syndr 5:255. doi:10.4172/2161-1017.1000255

Copyright: © 2016 Frankel AH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Insulin resistance accompanies many well-established cardiovascular risk factors, such as obesity, hypertension, dyslipidaemia and type 2 diabetes. Since cardiovascular disease (CVD) is the leading cause of death in patients with end stage renal disease (ESRD), insulin resistance is thought to play a role in the morbidity and mortality associated with ESRD. This paper reviews the available information on insulin resistance in patients with impaired kidney function as well as those on renal replacement therapy in the form of maintenance hemodialysis. Potential mechanisms for the dynamic changes in insulin resistance, which occur through the different stages of kidney disease, are also discussed. We hypothesize that stabilizing insulin sensitivity may have a positive effect on improving outcome in ESRD subjects.

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