alexa Effect of Inulin from Agave tequilana Weber Blue Variety on the Metabolic Profile of Overweight and Obese Dyslipidemic Patients
ISSN: 2167-0870

Journal of Clinical Trials
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Research Article

Effect of Inulin from Agave tequilana Weber Blue Variety on the Metabolic Profile of Overweight and Obese Dyslipidemic Patients

Sandra Ofelia Hernández-González1*, Rosa Itzel Bricio-Ramírez2, Maria Guadalupe Ramos-Zavala2, Ana Bertha Zavalza-Gómez3, Ernesto Germán Cardona- Muñoz2, Leonel García-Benavides2, Esperanza Martínez-Abundis2 and Sara Pascoe-González2
1Unidad de Investigación Médica en Epidemiología Clínica, Unidad Médica de Alta Especialidad, Hospital de Especialidades, Centro Médico Nacional de Occidente, IMSS, Guadalajara, Jalisco, México
2Instituto de Terapéutica Experimental y Clínica (INTEC), Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, México
3División de Investigación en Salud, Unidad Médica de Alta Especialidad, Hospital de Ginecobstetricia, Centro Médico Nacional de Occidente del IMSS, Guadalajara, Jalisco, México
Corresponding Author : Sara Pascoe González
Sierra Mojada 950, piso 1, Edificio P
CP 44380, Guadalajara, México
Tel: +52-33-36173499
E-mail: [email protected]
Received: January 25, 2016 Accepted: February 15, 2016 Published: February 22, 2016
Citation: Hernández-González SO, Bricio-Ramírez RI, Ramos-Zavala MG, Zavalza-Gómez AB, Cardona-Muñoz EG, et al. (2016) Effect of Inulin from Agave tequilana Weber Blue Variety on the Metabolic Profile of Overweight and Obese Dyslipidemic Patients. J Clin Trials 6:254. doi:10.4172/2167-0870.1000254
Copyright: © 2016 Hernández-González SO, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Agave inulin is non-digestible/fermentable carbohydrates capable of counteracting metabolic related alterations through the modification of the gut microbiota. The fructo-oligosaccharide content of agave inulin differs from inulin extracted from chicory root. The aim of this study was to assess the efficacy and safety of agave inulin on the metabolic profile of overweight and obese dyslipidemic patients. An open clinical trial was carried out in 30 overweight and obese subjects, between 30 and 70 years old. All subjects received 15 g/day of inulin in the morning, during 60 days. Biochemical and metabolic profiles before and after pharmacological intervention were performed. After inulin administration, it was statistically significant decrease: fasting glucose levels (83.1 ± 13.4 vs. 76.5 ± 12.6 mg/dl; p=0.006), triglycerides and glucose (TyG) index (3.9 ± 0.1 vs. 3.8 ± 0.2; p=0.021) and urea (31.4 ± 8.6 vs. 26.3 ± 5.4 mg/dl; p=0.001), thus an increase in sodium levels (139.3 ± 3.0 vs.140.4 ± 2.1 mg/dl; p=0.021), was also found. Similarly, eventhough no statistical differences were detected for all cases, the serum concentration decreased 37% for total cholesterol (TC), 23% for LDL -c, 53% for total triglycerides (TG) and 63.3% for HBA1c while HDL-c levels increased. Anthropometric parameters did not change within the group and the soluble fiber intake did not produce any important gastrointestinal adverse effects. In this study, the increased fiber intake of inulin from Agave tequilana Weber blue variety was effective and safe in reducing glucose and urea levels as well as insulin resistance in overweight and obese dyslipidemic patients; however, sodium levels were increased but were not clinically significant.

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