alexa Effect of Lentil and Buffalo Whey Protein Hydrolysates on Histopathology of Liver and Kidney in Diabetic Rats | OMICS International| Abstract
ISSN: 2157-7099

Journal of Cytology & Histology
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  • Research Article   
  • J Cytol Histol 2017, Vol 8(5): 489
  • DOI: 10.4172/2157-7099.1000489

Effect of Lentil and Buffalo Whey Protein Hydrolysates on Histopathology of Liver and Kidney in Diabetic Rats

Gehan Hassan Bisar1, Mokhtar Youssef2, Khaled El Saadany3, Wedad Mohamed El-Kholy1 and Ehab Kheadr3*
1Dairy Research Department, Food Technology Research Institute, , A.R.C., Cairo, Egypt
2Postgraduate Studies and Research Institute, Alexandria University, Alexandria, Egypt
3Department of Dairy Science and Technology, Faculty of Agriculture, Functional Foods and Nutraceuticals Laboratory (FFNL), Alexandria University, Postal Code 21545 Alexandria, Egypt
*Corresponding Author : Ehab Kheadr, Department of Dairy Science and Technology, Faculty of Agriculture, Functional Foods and Nutraceuticals Laboratory (FFNL), Alexandria University, Postal Code 21545 Alexandria, Egypt, Tel: +203-5921960; +203-5921862; +203-5915427, Fax: +203-5922780, Email: [email protected]

Received Date: Nov 01, 2017 / Accepted Date: Nov 25, 2017 / Published Date: Dec 04, 2017

Abstract

This study was undertaken to evaluate the effects of protein hydrolysate prepared from lentil and buffalo whey proteins on body weight and histopathology of alloxan induced diabetic rats. Seventy two male albino rats were randomly divided into non-diabetic, diabetic untreated and diabetic treated with lentil or buffalo whey protein hydrolysates with or without yogurt. Experimental diabetes was induced by a single intraperitoneal (i.p) administration of alloxan (120 mg/kg body weight). Histopathological analyses were conducted on the liver and kidney tissues after 28 day of experiment. While the body weight was significantly decreased in the diabetic control group, there were no significant difference in diabetic treated group (P<0.05). Destruction of the liver architecture of the hepatocytes in the diabetic group showed the signs of steatosis, fibrosis and inflammation in the central vein and blood vessels. In the kidney, intestinal nephrites and mesangial proliferation and formation of cast material were observed. Yoghurt-containing lentil protein hydrolysate contained in yogurt appeared to have remarkable effect to prevent damage in liver and kidney histology caused by diabetes.

Keywords: Active peptides; Legumes; Whey proteins; Diabetes; Yoghurt

Citation: Bisar GH, Youssef M, Saadany KE, El-Kholy W, Kheadr E (2017) Effect of Lentil and Buffalo Whey Protein Hydrolysates on Histopathology of Liver and Kidney in Diabetic Rats. J Cytol Histol 8: 489. Doi: 10.4172/2157-7099.1000489

Copyright: © 2017 Bisar GH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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