alexa Effect of LLLI on Expression of Micro RNA-21 and Ventri
ISSN: 1745-7580

Immunome Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Effect of LLLI on Expression of Micro RNA-21 and Ventricular Remodeling in Rats after AMI

Firoj MK*, Fa XE and Yu HB

Department of Cardio-vascular Surgery, 2nd affiliated hospital of Zhengzhou University, Zhengzhou, Henan, P.R China

*Corresponding Author:
Mohammed Firoj Khan
Department of Cardio-vascular Surgery
2nd affiliated hospital of Zhengzhou University
Zhengzhou, Henan, P.R China
Tel: +8615237140996
E-mail: [email protected]

Received date: May 30, 2016; Accepted date: August 03, 2016; Published date: August 10, 2016

Citation: Firoj MK, Fa XE, Yu HB (2016) Effect of LLLI on Expression of Micro RNA-21 and Ventricular Remodeling in Rats after AMI. Immunome Res 12:118. doi:10.4172/1745-7580.10000118

Copyright: © 2016 Firoj MK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Objective: To assess the effects of low-level laser irradiation (LLLI) on the expression of micro RNA-21 and ventricular remodelling in the model of rat myocardial infarction. Methods: 110 adult-female SD rats were randomly divided into sham operation (30), control (40), and treatment (40) groups. MI model was prepared by ligation of left anterior descending artery in the control and treatment groups while simply threading at the same site of MI model in sham group. LLLI treated using (635 nm, 6mW, 125s, 0.96 J/cm2) after three weeks of MI at infarct region in the treatment group. At 1 h, 24 h, 48 h, 72 h and 7 d after LLLI treatment, the expression of miR-21 at the infracted myocardial tissue were detected using qRT-PCR. At the end of 4 weeks after MI, hearts were harvested for histological analysis. Results: MiR-21 expression in the treatment group was lower than both sham group as well as the control group (P<0.05). LVEF (%) and LVFS (%) in the treatment group before and after LLLI; (39.37 ± 1.35 vs. 47.62 ± 2.75, P<0.05; (19.23 ± 3.12) vs (24.15± 2.53), P<0.05). Collagen fiber content in treatment group were significantly lower than control group (28.79 ± 2.06%) vs (69.22 ± 3.64%), (P<0.05). Conclusion: LLLI treatment of myocardial infarction can significantly down regulate the expression of tissue miR-21 in the infarct region, increase left ventricular function and decrease collagen fiber content suggesting the beneficial effect of LLLI on delaying myocardial fibrosis, reduce the pathological ventricular remodelling (VR) after MI.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords