Effect of Low Dose of Butylparaben on Liver Weight of Ovariectomised C3H Albino Mice
Butylparaben is widely used in man’s daily used products like pharmaceuticals, cosmetics and foodstuff as a preservative for having good anti microbial activity. In many in vivo experimental studies in CD1 and CF1 mice, butylparaben elicit toxic effect in various organs including liver, thyroid, kidney, spleen, reproductive organs. However, the effects of butylparaben on organs showed strain differences in sensitivity. In this experiment, effect of low dose of butylparaben on weight of liver was studied in C3H albino mice. For the experiment three doses of butylparaben of 10 mg/Kg body weight/day, 50 mg/Kg body weight/day and 100 mg/Kg body weight/day was considered. The ovariectomised C3H albino mice were grouped as vehicle control (olive oil), positive control (estradiol) and the above three doses of butylparaben and were administered with the doses for seven consecutive days through subcutaneous route of administration. After the short-term exposure of seven consecutive days, butylparaben was found to exert a dose dependent change in liver weight of ovariectomised C3H albino mice. Positive control (estradiol) showed a significant increase in liver weight (p<0.01) compared to as vehicle control (olive oil).10 mg/Kg body weight/day and 100 mg/Kg body weight/day showed a significant increase in liver weight (p<0.01) compared to as vehicle control (olive oil). However, 50 mg/Kg body weight/day showed a non-significant decrease in liver weight compared to as vehicle control (olive oil).