alexa Effect of L-Thyroxine Therapy on Musculoskeletal Sympto
ISSN: 2161-1149

Rheumatology: Current Research
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Effect of L-Thyroxine Therapy on Musculoskeletal Symptoms of Hypothyroidism

Fathia Ehmouda Zaid*, Emhmmed Eljazwi and Najat Eldrasi

Department of Rheumatology, Department of Endocrinology, Benghazi University, Libya

*Corresponding Author:
Fathia Ehmouda Zaid
Assistant Professor, Faculty of Medicine
Benghazi University, Libya
Tel: 0193424950
E-mail: [email protected]

Received date: September 16, 2015; Accepted date: October 15, 2015; Published date: October 26, 2015

Citation: Zaid FE, Eljazwi E, Eldrasi N (2015) Effect of L-Thyroxine Therapy on Musculoskeletal Symptoms of Hypothyroidism. Rheumatology (Sunnyvale) 5:172. doi: 10.4172/2161-1149.1000172

Copyright: © 2015 Zaid FE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Introduction: Hypothyroid rheumatic syndromes, ranging from myalgia and arthralgia to true myopathy and arthritis are due to thyroid dysfunction. Our purpose was to assess the effect of L-thyroxine therapy on musculoskeletal symptoms. Patients and methods: A follow up study was done which included patients diagnosed with hypothyroidism and a history of musculoskeletal symptoms. They were interviewed with a structured questionnaire about their past and current musculoskeletal complaints, undergoing follow-up assessment from 3 to 12 months from baseline. The data was analyzed statistically. The correlation between recovery musculoskeletal symptoms on L-thyroxine therapy and various variable factors of hypothyroidism was evaluated by Pearson's correlation coefficient. A value of p<0.05 was considered significant. Results: Seventy five patients diagnosed with hypothyroidism had musculoskeletal symptoms the musculoskeletal of hypothyroidism, most patients had arthralgia (72%), carpal tunnel syndrome (61.3%), frozen shoulder (37.3%), myalgia (36%), myopathy (12%) and arthritis (10.6%) the connective tissue disease association with hypothyroidism, patients had rheumatoid arthritis (14.7%), osteoarthritis (17.3%), fibromyalgia (13.3%) and systemic lupus erythematosus (2.7%). The management of musculoskeletal symptoms patients were start l thyroxine therapy (33.3%), patients were on same dose of l thyroxine (20%), patients were increase dose of l thyroxine (46.7%). Patients were given non-steroidal anti-inflammatory drugs (49.3%), physiotherapy (38.7%) and were undergone with reduction of weight (25.9%). Some musculoskeletal symptoms disappeared (66.7%), while some were unrecovered (33.3%). The strong correlation between recovery musculoskeletal symptoms of hypothyroidism and various variable factors like age, duration of hypothyroidism disease, co morbidity diseases and level TSH. Conclusion: The musculoskeletal symptoms of hypothyroidism were improved by L-thyroxine treatment.


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