alexa Effect of Magnesium Sulfate on the Total Anesthetic and Analgesic Requirements in Neurosurgery
ISSN: 2155-9562

Journal of Neurology & Neurophysiology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)


Effect of Magnesium Sulfate on the Total Anesthetic and Analgesic Requirements in Neurosurgery

Essam M. Manaa1,2* and Amro F. Alhabib3

1Anesthesia Department, College of Medicine, Assiut University Hospital, Assiut, Egypt

2Anesthesia Department, College of Medicine, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia

3Neurosurgery Department, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia

Corresponding Author:
Essam M. Manaa
Anesthesia Department, Assiut University Hospital
College of Medicine, Assiut, Egypt
Anesthesia Department (41), King Khalid University Hospital
King Saud University, Riyadh, Saudi Arabia
Tel: 00966509870124
Fax: 0096614692366
E-mail: [email protected]

Received date: June 12, 2012; Accepted date: June 27, 2012; Published date: June 30, 2012

Citation: Manaa EM, Alhabib AF (2012)Effect of Magnesium Sulfate on the Total Anesthetic and Analgesic Requirements in Neurosurgery. J Neurol Neurophysiol S11-001. doi:10.4172/2155-9562.S11-001

Copyright: © 2012 Manaa EM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Background: Anesthesia for neurosurgery requires balancing deep and effective anesthesia as well as
postoperative analgesia versus the risks of delayed recovery and postoperative respiratory depression. This
randomized, placebo-controlled, double-blind study was designed to evaluate the effect of magnesium sulfate on the
total anesthetic and analgesic consumption using the clinical parameters in addition to the bispectral index (BIS) and
neuromuscular monitoring using train-of-four (TOF).
Patients and Methods: This study included 60 adult male and female patients, ASA physical status I and II,
and undergoing neurosurgical procedures. Patients were randomly allocated into 2 equal groups. Patients in group
I (magnesium group) received magnesium sulfate (20 mg/kg) as bolus dose over 5 minutes before induction of
anesthesia, followed by 10 mg/kg/h as infusion. While patients in group II (control group) received saline with the
same bolus and infusion rates. All patients were induced by fentanyl (2 μg/kg), propofol (1.5-2 mg/kg) and rocuronium
in a dose of (0.6 mg/kg) to facilitate tracheal intubation. This was followed by continuous infusion of propofol (6-10
mg/kg/h) and fentanyl (1-2 μg/kg/h).
Results: Results showed that total consumptions of fentanyl, propofol and rocuronium were significantly less
(P < 0.05) in magnesium group when compared to control group. Recovery time was significantly shorter (P < 0.05)
in magnesium group. Postoperative pain score as well as total analgesic requirement of morphine was significantly
lower (P < 0.05) in magnesium group compared to control group.
Conclusion: Magnesium sulfate reduces the total anesthetic and analgesic requirements as well as postoperative


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version