alexa Effect of Manasamitra Vatakam Against Aluminium Induced Learning and Memory Impairment of Apoptosis in Rat ’ s Hippocampus and Cortex
ISSN: 2157-7609

Journal of Drug Metabolism & Toxicology
Open Access

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Research Article

Effect of Manasamitra Vatakam Against Aluminium Induced Learning and Memory Impairment of Apoptosis in Rat ’ s Hippocampus and Cortex

Thirunavukkarasu SV1*, Jayanthi M2, Raja S3 and Venkataraman S4

1Medical Cyclotron Facility, HCG Health Care Ltd, Kamakshi Memorial Hospital Campus, Chennai-600 100, Tamil Nadu, India

2Department of Chemistry, Pachaiyappa’s College, Chennai-600 030, Tamilnadu, India

3GITAM Institute of Pharmacy, GITAM University, Visakhapatnam- Andhra Pradesh, India-530045

4Department of Pharmacology, C.L. Baid Metha College of Pharmacy and Research Foundation, Chennai – 600 097, Tamilnadu, India

*Corresponding Author:
Dr. Thirunavukkarasu
Research officer cum Chief Radio Chemist, Medical Cyclotron Facility
Dr. Kamakshi Memorial Hospital, Pallikaranai
Chennai – 600100, Tamilnadu, India
Tel: +91-44-66300300, 22469200
Fax: +91- 44-66300500
E-mail: [email protected]

Received date: April 28, 2013; Accepted date: June 14, 2013; Published date: June 17, 2013

Citation: Thirunavukkarasu SV, Jayanthi M, Raja S, Venkataraman S (2013) Effect of Manasamitra Vatakam Against Aluminium Induced Learning and Memory Impairment of Apoptosis in Rat’s Hippocampus and Cortex. J Drug Metab Toxicol 4:154. doi: 10.4172/2157-7609.1000154

Copyright: © 2013 Thirunavukkarasu SV, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

The present study investigates

neuronal cell

death and neuroprotective effect of Manasamitra vatakam ( MMV ) against Aluminum (Al)-induced toxicity in rats. Aluminum and its salts extensively damaged nervous system and impaired learning and memory animals in neurodegenerative disease. In this study were conducted five groups, six animals in each group. In these study reveals Al caused neuronal apoptosis and cognitive dysfunction of animals brain regions (Hippocampus and Cortex) that could be restrain by treated with Manasamitra vatakam. MMV is a herbo-mineral formulation and prepared on the basis of Indian system of

Ayurvedic medicine

. These formulations using psychiatric treatment in Indian scenario, obviously tried for alternative treatment against Aluminium induced cognitive dysfunctions. It causes synthesis, release of neurotransmitter 5-hydroxytryptamine (5-HT), antioxidants, inhibit apoptotic genes and improve

cognitive functions

of animals. Apoptotic, anti-apoptotic genes such as Bcl-2, Bcl-xL and caspas-3 were estimated by Western blot and Reverse transcriptase polymerase chain reaction (RT- PCR). In these results clearly observed that MMV treatment was markedly increased 5-HT and restrain cognitive functions as well as decreased expression of pro-apoptotic genes against Al induced animals . This result indicates MMV could activate learning and memory function of animals due to inhibition of apoptotic genes like Bcl-2, Bcl-xL and caspas-3 . The present study reveals that Ayurvedic formulation of Manasamitra vatakam ( MMV) as potentially inhibited neuronal apoptosis and enhanced

cognitive function

leads to learning memory function against Al induced neuodegenerative disease.

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