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Effect of Myrtus Communis L. Extracts on Attenuation of Liver Normothermic Ischemia-Reperfusion Injury | OMICS International | Abstract
ISSN: 2161-0991

Journal of Transplantation Technologies & Research
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Review Article

Effect of Myrtus Communis L. Extracts on Attenuation of Liver Normothermic Ischemia-Reperfusion Injury

Henda Ferchichi1, Issam Salouage1,2*, Sarra Bacha1, Dorra Ben Said1, Emna Gaies1,2, Mohamed Boussaid3, Mohamed Lakhal1 and Anis Klouz1,2

1Centre National de Pharmacovigilance – Tunis, Tunisia

2Unité d’Expérimentation Animale, Faculté de Médecine de Tunis, Tunisia

3Institut National des Sciences Appliquées et de Technologie INSAT, Tunisia

*Corresponding Author:
Issam Salouage
Unité d’Expérimentation Animale
Faculté de Médecine de Tunis, Tunisia
E-mail : [email protected]

Received Date: September 12, 2011; Accepted Date: November 14, 2011; Published Date: November 18, 2011

Citation: Ferchichi H, Salouage I, Bacha S, Said DB, Gaies E, et al. (2011) Effect of Myrtus Communis L. Extracts on Attenuation of Liver Normothermic Ischemia-Reperfusion Injury. J Transplant Technol Res S3: 001. doi: 10.4172/2161-0991.S3-001

Copyright: © 2011 Ferchichi H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


The Common Myrtle (Myrtus communis L.) is rich in antioxidants, particularly in anthocyanin. It was recognized for its anti-inflammatory and anti-thrombotic effects.

The aim of our work is to evaluate the effect of Common Myrtle on a model of hepatic ischemia-reperfusion in Rat.

Two morphs were chosen: white fruit Myrtle and black fruit Myrtle. Within each morph, fruit and leaf were separated and obtained extract were used to determine their effects on the hepatic model of ischemia-reperfusion.

Our work was conducted in three steps (1) Induction of hepatic ischemia (90 minutes) in Wistar Rat (2) injection of the Myrtle extract during 15 minutes before reperfusion (3) and reperfusion (2 hours).

To evaluate the effect of Myrtle on ischemia-reperfusion, we have monitored transaminases levels, Monoethylglycinexylidide (MEGX) concentrations (to assess the liver metabolic capacity) and Malondialdehyde (MDA) concentration.

The determination of total phenol extracts of Myrtle showed a significant difference between black fruit Myrtle (11.3 μg/ml), white fruit (27 μg/ml) and black fruit Myrtle leaves (94.3 μg/ml). The latter presented the highest antioxidant activity (86.54%).

With the extract from the white fruit of Myrtle, we noted a decrease of AST and ALT, respectively, 1321 U/I and 773 U/I compared with I/R group was 5757 U/I and 5404 U/I and an increase in the MEGX concentrations and decrease in MDA.

The testing of extracts of Myrtle in a model of hepatic ischemia showed a difference in the protective power against damage of ischemia-reperfusion, by origin and type of fruit (black or white).


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