alexa Effect of Narrowband Ultraviolet B Therapy on Serum Vit
ISSN: 2329-6887

Journal of Pharmacovigilance
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Research Article

Effect of Narrowband Ultraviolet B Therapy on Serum Vitamin D in Saudi Patients with Vitiligo

Abdulaziz A Alnoshan1*, Amal Al-Najjar2, Fatimah M Al-Mutairi3 and Reem Saad Alsubiae3
1Department of Dermatology, Security Forces Hospital, Riyadh, Saudi Arabia
2Pharmacy Services, Security Forces Hospital Riyadh, Kingdom of Saudi Arabia
3College of Pharmacy, Princess Nourah bint Abdulrahman University Riyadh, Kingdom of Saudi Arabia
*Corresponding Author : Abdulaziz A Alnoshan
Consultant, Head of Dermatology Division
Security Forces Hospital
Riyadh, Kingdom of Saudi Arabia
Tel: +966 50 555 1144
E-mail: [email protected]
Received February 16, 2016; Accepted February 23, 2016; Published February 29, 2016
Citation: Alnoshan AA, Al-Najjar A, Al-Mutairi FM, Alsubiae RS (2016) Effect of Narrowband Ultraviolet B Therapy on Serum Vitamin D in Saudi Patients with Vitiligo. J Pharmacovigilance 4:198. doi:10.4172/2329-6887.1000198
Copyright: © 2016 Alnoshan AA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Objective: To evaluate the effect of NB-UVB therapy on serum levels of 25-hydroxyvitamin D [25(OH)D] in Saudi patients with vitiligo.

Method: We estimated the levels of 25-hydroxy vitamin D [25(OH)D] before, and after NB-UVB radiation in patients with vitiligo who did not take vitamin D supplement. A comparison was done between subsets of patients concerning gender and duration of treatment of NB-UVB.

Results: There were 39 patients with vitiligo. Females were 22 (56.4%) and males were 17 (43.6%).The mean vitamin D level before NB-UVB treatment was 29.575 ± 16.315 nmol/L. while vitamin D level was increased to 78.871 + 22.776 after treatment with significant differences (P < 0.0001). The males had mean vitamin D level 36.232 ± 19.505 nmol/L, while females had mean vitamin D level 24.431 ± 11.321 nmol/L at baseline. After NB-UVB treatment the males had vitamin D level of 78.888 ± 25.683 nmol/L. While females had mean vitamin D level78.859 ± 20.884 nmol/L. After 6 months of the NB-UVB treatment the delta change in vitamin D level was 38.888 ± 20.255 nmol/L while after 12 - 24 months of treatment with NB-UVB the delta change in vitamin D level was 60.252 ± 17.565 nmol/L (P = 0.001).

Conclusion: Patients who received narrow band ultra violet B radiation at wave length 309 nm as treatment of vitiligo are less likely to need vitamin D supplement to correct their vitamin D deficiency. More studies are needed in order to confirm these results and to establish UVB as treatment modalities to correct vitamin D levels in patients who cannot absorb vitamin D either orally or parentally.

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