Effect of Narrowband Ultraviolet B Therapy on Serum Vitamin D in Saudi Patients with Vitiligo
|Abdulaziz A Alnoshan1*, Amal Al-Najjar2, Fatimah M Al-Mutairi3 and Reem Saad Alsubiae3|
|1Department of Dermatology, Security Forces Hospital, Riyadh, Saudi Arabia|
|2Pharmacy Services, Security Forces Hospital Riyadh, Kingdom of Saudi Arabia|
|3College of Pharmacy, Princess Nourah bint Abdulrahman University Riyadh, Kingdom of Saudi Arabia|
|*Corresponding Author :||Abdulaziz A Alnoshan
Consultant, Head of Dermatology Division
Security Forces Hospital
Riyadh, Kingdom of Saudi Arabia
Tel: +966 50 555 1144
E-mail: [email protected]
|Received February 16, 2016; Accepted February 23, 2016; Published February 29, 2016|
|Citation: Alnoshan AA, Al-Najjar A, Al-Mutairi FM, Alsubiae RS (2016) Effect of Narrowband Ultraviolet B Therapy on Serum Vitamin D in Saudi Patients with Vitiligo. J Pharmacovigilance 4:198. doi:10.4172/2329-6887.1000198|
|Copyright: © 2016 Alnoshan AA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
Objective: To evaluate the effect of NB-UVB therapy on serum levels of 25-hydroxyvitamin D [25(OH)D] in Saudi patients with vitiligo.
Method: We estimated the levels of 25-hydroxy vitamin D [25(OH)D] before, and after NB-UVB radiation in patients with vitiligo who did not take vitamin D supplement. A comparison was done between subsets of patients concerning gender and duration of treatment of NB-UVB.
Results: There were 39 patients with vitiligo. Females were 22 (56.4%) and males were 17 (43.6%).The mean vitamin D level before NB-UVB treatment was 29.575 ± 16.315 nmol/L. while vitamin D level was increased to 78.871 + 22.776 after treatment with significant differences (P < 0.0001). The males had mean vitamin D level 36.232 ± 19.505 nmol/L, while females had mean vitamin D level 24.431 ± 11.321 nmol/L at baseline. After NB-UVB treatment the males had vitamin D level of 78.888 ± 25.683 nmol/L. While females had mean vitamin D level78.859 ± 20.884 nmol/L. After 6 months of the NB-UVB treatment the delta change in vitamin D level was 38.888 ± 20.255 nmol/L while after 12 - 24 months of treatment with NB-UVB the delta change in vitamin D level was 60.252 ± 17.565 nmol/L (P = 0.001).
Conclusion: Patients who received narrow band ultra violet B radiation at wave length 309 nm as treatment of vitiligo are less likely to need vitamin D supplement to correct their vitamin D deficiency. More studies are needed in order to confirm these results and to establish UVB as treatment modalities to correct vitamin D levels in patients who cannot absorb vitamin D either orally or parentally.