alexa Effect of Nelumbo nucifera Stamen Extract on Phagocytosis and Malaria Parasite Growth Against Plasmodium Berghei Infected Mice | OMICS International | Abstract
ISSN: 2470-6965

Malaria Control & Elimination
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Research Article

Effect of Nelumbo nucifera Stamen Extract on Phagocytosis and Malaria Parasite Growth Against Plasmodium Berghei Infected Mice

Piyaporn Ratananinsruang1, Bu-Nga Taowbud1, Pattraporn Ountuang2 and Voravuth Somsak2*

1Department of Clinical Immunology, Faculty of Medical Technology, Western University, Kanchanaburi 71170, Thailand

2Department of Clinical Chemistry, Faculty of Medical Technology, Western University, Kanchanaburi 71170, Thailand

*Corresponding Author:
Voravuth Somsak
Department of Clinical Chemistry
Faculty of Medical Technology
Western University, Kanchanaburi 71170
Thailand
Tel: +66898009939
E-mail: [email protected]

Received Date: September 16, 2015; Accepted Date: November 04, 2015; Published Date: November 11, 2015

Citation:Ratananinsruang P, Taowbud BN, Ountuang P, Somsak V (2015) Effect of Nelumbo nucifera Stamen Extract on Phagocytosis and Malaria Parasite Growth Against Plasmodium Berghei Infected Mice. Malar Cont Elimination S1-004. doi:10.4172/ 2470-6965.1000S1-004

Copyright: © 2015 Ratananinsruang P. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Antimalarial drug resistant malaria parasites are causing not only the spread of malaria to new areas but also its re-emergence in areas where it had previously been eradicated. In addition, malaria-associated impairment of phagocytosis has been reported during malaria parasite infection. The present study has been carried out to investigate the effect of Nelumbo nucifera stamen extract on phagocytosis and malaria parasite growth against Plasmodium berghei infected mice. Groups of ICR mice were treated orally by gavage with N. nucifera stamen extract (500, 1,000 and 2,000 mg/kg) after infection with P. berghei ANKA. Parasitemia, percent phagocytosis and phagocytic index were determined. At these doses, N. nucifera stamen extract inhibited parasitemia in dose-dependent manner, with similar level of antimalarial activity to chloroquine (5 mg/kg). In addition, increasing of phagocytosis and phagocytic index has also been observed in dose-dependent in infected mice treated with the extracts. In particularly, the highest activities of N. nucifera stamen extract were found at dose 2,000 mg/kg. These results indicated that aqueous crude extract of N. nucifera stamens have antimalarial and improve phagocytic activity against P. berghei ANKA infected mice.

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