alexa Effect of Nicotine-free Tobacco Extract on DNA Damage R
ISSN: 2157-2518

Journal of Carcinogenesis & Mutagenesis
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Effect of Nicotine-free Tobacco Extract on DNA Damage Responses in Cancerous and Non-cancerous Cells

Ying Yu1,2, Pavan K Soma1, Y Martin Lo1, Cheng-I Wei1 and Wen-Hsing Cheng1*
1Department of Nutrition and Food Science, University of Maryland, College Park, MD, 20742, USA
2College of Life Sciences, Northwest A & F University, Yangling, Shannxi, 712100, China
Corresponding Author : Wen-Hsing Cheng
Department of Nutrition and Food Science
University of Maryland
0112 Skinner Building
College Park, MD 20742, USA
Tel: +1-301-405-2940
Fax: +1-301-314-3313
E-mail: [email protected]
Received February 02, 2012; Accepted February 24, 2012; Published February 28, 2012
Citation: Yu Y, Soma PK, Lo YM, Wei CL, Cheng WH (2012) Effect of Nicotine-free Tobacco Extract on DNA Damage Responses in Cancerous and Non-cancerous Cells. J Carcinogene Mutagene S3:002. doi: 10.4172/2157-2518.S3-002
Copyright: © 2012 Yu Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


The use of cigarette products tags tobacco as a crop with serious health concerns, but nutraceutical potentials of tobacco constituents other than nicotine have not been adequately explored. The objective of this study was to investigate the effect of nicotine-free tobacco extract on the activation of tumorigenesis barriers. Four lines of human cells were treated with a nicotine-free tobacco extract (0.1 and 1 mg/mL, 0-48 h). MRC-5 and CCD841 non-cancerous cells treated with the tobacco extract showed hypersensitivity, apoptosis and cell cycle arrest in S and G2/M phases, and induction of DNA damage response as evidenced by phosphorylation of ataxia telangiectasia mutated at Ser- 1981 and histone H2A.X at Ser-139. In contrast, HCT 116 cancerous cells, with or without functional DNA mismatch repair, were resistant to the tobacco extract treatment. These results suggest that tobacco components other than nicotine may have a chemoprevention potential that stifles tumorigenesis at the early stage of tumorigenesis


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version