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ISSN: 2157-2518

Journal of Carcinogenesis & Mutagenesis
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Research Article

Effect of Nicotine-free Tobacco Extract on DNA Damage Responses in Cancerous and Non-cancerous Cells

Ying Yu1,2, Pavan K Soma1, Y Martin Lo1, Cheng-I Wei1 and Wen-Hsing Cheng1*

1Department of Nutrition and Food Science, University of Maryland, College Park, MD, 20742, USA

2College of Life Sciences, Northwest A & F University, Yangling, Shannxi, 712100, China

*Corresponding Author:
Wen-Hsing Cheng
Department of Nutrition and Food Science
University of Maryland
0112 Skinner Building
College Park, MD 20742, USA
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Received date: February 02, 2012; Accepted date: February 24, 2012; Published date: February 28, 2012

Citation: Yu Y, Soma PK, Lo YM, Wei CL, Cheng WH (2012) Effect of Nicotine-free Tobacco Extract on DNA Damage Responses in Cancerous and Non-cancerous Cells. J Carcinogene Mutagene S3:002. doi: 10.4172/2157-2518.S3-002

Copyright: © 2012 Yu Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The use of cigarette products tags tobacco as a crop with serious health concerns, but nutraceutical potentials of tobacco constituents other than nicotine have not been adequately explored. The objective of this study was to investigate the effect of nicotine-free tobacco extract on the activation of tumorigenesis barriers. Four lines of human cells were treated with a nicotine-free tobacco extract (0.1 and 1 mg/mL, 0-48 h). MRC-5 and CCD841 non-cancerous cells treated with the tobacco extract showed hypersensitivity, apoptosis and cell cycle arrest in S and G2/M phases, and induction of DNA damage response as evidenced by phosphorylation of ataxia telangiectasia mutated at Ser- 1981 and histone H2A.X at Ser-139. In contrast, HCT 116 cancerous cells, with or without functional DNA mismatch repair, were resistant to the tobacco extract treatment. These results suggest that tobacco components other than nicotine may have a chemoprevention potential that stifles tumorigenesis at the early stage of tumorigenesis

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