alexa Effect of Pre-Existing Immunity to Flaviviruses on Bala
ISSN: 2157-7560

Journal of Vaccines & Vaccination
Open Access

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Research Article

Effect of Pre-Existing Immunity to Flaviviruses on Balanced Induction of Neutralizing Antibodies by a Dengue Tetravalent DNA Vaccine in Mice

Eiji Konishi1,2* and Yamato Takizawa1

1Division of Infectious Diseases, Department of International Health, Kobe University Graduate School of Health Sciences, 7-10-2 Tomogaoka, Suma-ku, Kobe 654-0412, Japan

2Division of Vaccinology, Department of Microbiology and Infectious Diseases, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650- 0017, Japan

*Corresponding Author:
Dr. Eiji Konishi
Department of International Health
Kobe University Graduate School of Health Sciences
Kobe, Japan, 7-10-2 Tomogaoka
Suma-ku, Kobe 654-0142, Japan
Tel/Fax: +81-78-796-4594
E-mail: ekon@

Received Date: July 30, 2010; Accepted Date: September 25, 2010; Published Date: September 28, 2010

Citation: Konishi E, Takizawa Y (2010) Effect of Pre-Existing Immunity to Flaviviruses on Balanced Induction of Neutralizing Antibodies by a Dengue Tetravalent DNA Vaccine in Mice. J Vaccines Vaccin 1:102. doi: 10.4172/2157-7560.1000102

Copyright: © 2010 Konishi E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



We previously demonstrated that a DNA-based tetravalent dengue vaccine can induce balanced neutralizing antibody responses against all four types of dengue virus (DENV1–4), using naïve mice. On the other hand, individuals receiving the dengue vaccine may have previously been infected with dengue virus (DENV1–4) or vaccinated with other fl avivirus vaccines. Thus, we investigated the effect of preimmunity against fl aviviruses on immunogenicity of a dengue tetravalent DNA vaccine in mice. Mice preimmunized with DENV2 developed higher antibody levels against DENV2 than other types of dengue virus after the fi rst dengue vaccination. However, the second vaccination provided similar increases (4- to 8-fold) in antibody levels against all types of dengue virus, compared with non-preimmunized mice. Preimmunization with yellow fever or Japanese encephalitis vaccines did not affect the immunogenicity of the tetravalent vaccine, except for slight and occasional increases in antibody levels against certain types of viruses. Thus, the dengue tetravalent DNA vaccine could provide balanced induction of dengue antibody responses even in mice preimmunized with any of the three fl aviviruses, at least after the second vaccination.


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