Effect of Substitution Therapy on the Birth Weight of Newborns, Postpartum Adaptation, Trophism and Course of the Neonatal Abstinence SyndromeVavrinková B* and Binder T
Department of Gynecology and Obstetrics of the Teaching Hospital and the 2nd Medical Faculty of Charles University in Prague, V Úvalu 85, Prague
- *Corresponding Author:
- Blanka Vavrinkova
Department of Gynecology and Obstetrics of the Teaching Hospital and
the 2nd Medical Faculty of Charles University in Prague
V Úvalu 85, 150 06 Prague, Czech Republic
E-mail: [email protected]
Received date: March 02, 2012; Accepted date: May 17, 2012; Published date: May 19, 2012
Citation: Vavrinková B, Binder T (2012) Effect of Substitution Therapy on the Birth Weight of Newborns, Postpartum Adaptation, Trophism and Course of the Neonatal Abstinence Syndrome. Med chem 2:092-096. doi:10.4172/2161-0444.1000121
Copyright: © 2012 Vavrinková B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Aim: Evaluation of the effect of substitution therapy on the birth weight of the newborn, its postpartum adaptation and course of the neonatal abstinence syndrome.
Patients and methods: We studied heroin-addicted women and women undergoing methadone and buprenorphine substitution. During the 3 years we concentrated on 47 heroin-addicted women and 60 women under substitution for prenatal screening, labour and delivery.
Results: Birth weight of newborns was lowest in the group of heroin-addicted women as compared to the group receiving substitution with buprenorphine p < 0.01 and to the group of methadone-substituted patients p < 0.05. The highest number of changes in the placenta was exhibited by heroin users, both when compared to methadone users (p < 0.01) and buprenorphine users (p < 0.001). The highest statistically significant number of newborns with IUGR symptoms were born to heroin-addicted women. The lowest Apgar score was recorded in all three evaluations in the group of buprenorphine users and the highest in methadone-substituted women.
Conclusions: Substitution therapy provides pregnant women with the possibility of social stabilization and
adequate prenatal care. With regard to the fact that methadone substitution protracts the newborn´s abstinence syndrome, attention has been recently focused on substitution with buprenorphine that seems to be from this viewpoint a more considerate option.