Effect of the Endoplasmic Reticulum Stress on Diabetes Mellitus Type 2 in Hypothalamic Cells
- *Corresponding Author:
- Caroline Mesquita
Scientific Researcher of Pharma Nostra and PhD in Pharmacology
Department of Pharmacology, Faculty of Medical Sciences, UNICAMP, Brazil
E-mail: [email protected]
Received date: September 23, 2015; Accepted date: June 20, 2016; Published date: June 29, 2016
Citation: Mesquita C, Ferreira D, Assaly V (2016) Effect of the Endoplasmic Reticulum Stress on Diabetes Mellitus Type 2 in Hypothalamic Cells. Endocrinol Metab Syndr 5:243. doi:10.4172/2161-1017.1000243
Copyright: © 2016 Mesquita C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Unfolded protein response is an adaptive cellular response that adjust protein translation rate to specific external stress. This response has been demonstrated to mediate programmed cell death and insulin resistance in pathophysiological conditions such as diabetes. More recently, it has been demonstrated that the pharmacological activation of UPR in the hypothalamus is able to stimulate food intake through mechanism not completely determined.