alexa Effect of Triclosan on the Renal Cortex of Adult Male Albino Rats and the Possible Protective Role of Ellagic Acid: Histological and Biochemical Study | Abstract
ISSN: 2157-7099

Journal of Cytology & Histology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Effect of Triclosan on the Renal Cortex of Adult Male Albino Rats and the Possible Protective Role of Ellagic Acid: Histological and Biochemical Study

Zeinab A. Hassan1,2*, Manal R. Abd El-Haleem1 and Ghada N. Mansour3

1Department of Histology and Cell Biology, Faculty of Medicine, Zagazig University, Egypt

2Department of Anatomy, Faculty of Medicine, Tibah University, Madina, Saudi Arabia

3Forensic and Toxicology Department, Faculty of Medicine, Zagazig University, Egypt

*Corresponding Author:
Zeinab A. Hassan
Department of Histology and Cell Biology, Faculty of Medicine
Zagazig University, Zagazig, Egypt, Facultyof Medicine
Tibah University, Madinah, Saudi Arabia
Tel: 00201223467226
E-mail: [email protected]

Received Date: September 09, 2014; Accepted Date: October 16, 2014; Published Date: October 18, 2014

Citation: Hassan ZA, Abd El-Haleem MR, Mansour GN (2014) Effect of Triclosan on the Renal Cortex of Adult Male Albino Rats and the Possible Protective Role of Ellagic Acid: Histological and Biochemical Study. J Cytol Histol 5:285. doi: 10.4172/2157-7099.1000285

Copyright: 2014 Hassan ZA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Triclosan (TCS) is widely used broad spectrum bactericide. Ellagic acid (EA) has radical scavenging properties.
Aim of the work: to assess the structure of the renal cortex after TCS administration and to determine the possible protective role of EA.
Materials and Methods: Thirty adult male albino rats were divided into three groups; control group, TCS treated group: TCS was administered 200 mg/kg, once daily for six week, by oral gavages. TCS-EA treated group: received in the same doses of TCS and EA (30 mg/kg) for six weeks. Blood urea nitrogen (BUN), serum creatinine (Sc) and uric acids (UA) were measured. Renal cortex samples were processed for light and electron microscope examination.
Results: Examination of TCS treated group revealed increased glomerular cellularity in some corpuscles. Podocytes showed effacement of the foot processes and focal thickening of the glomerular basement membrane. Some tubules showed marked cellular disorganization. Disoriented basal mitochondria, areas of rarified cytoplasm and electron-dense bodies were noticed. Intense positive caspase-3 reaction was expressed in the tubular cells. TCS-EA showed improvement of morphological organization of renal cortex glomeruli, proximal and distal tubules with moderately expressed caspase-3 in renal tubules Statistical analysis showed significant increase of BUN, SC and BUN in TCS treated group in comparison with the control group.Their levels in TCS-EA treated group showed a significant decrease in comparison with TCS treated group
Conclusion: In conclusion, TCS leads to alterations in the histological structure and functions of renal cortex of albino rats and EA supplementation could protect from these changes.

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version