alexa Effect of Ubiquinone and Resveratrol on Experimentally

Journal of Research and Development
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Effect of Ubiquinone and Resveratrol on Experimentally Induced Parkinsonism

Ahmed M Kabel1* and Sanad S El Kholy2

1Pharmacology Department, Faculty of Medicine, Tanta University, Egypt

2Physiology Department, Faculty of Medicine, Tanta University, Egypt

*Corresponding Author:
Ahmed Mohammed Kabel
El-Geish street, Faculty of Medicine
Tanta University, Department of Pharmacology
Tanta, Egypt
Tel: 00201009041488
E-mail: [email protected]

Received Date: August 09, 2013; Accepted Date: August 13, 2013; Published Date: August 28, 2013

Citation: Kabel AM, El Kholy SS (2013) Effect of Ubiquinone and Resveratrol on Experimentally Induced Parkinsonism. J Res Development 1: 112 doi: 10.4172/2311-3278.1000112

Copyright: © 2013 Kabel AM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Parkinson's disease is one of the motor system diseases caused by factors that interfere with survival of the dopaminergic neurons in the substantia nigra. Its mechanisms include mitochondrial dysfunction, oxidative stress and neuroinflammation. Ubiquinone is a fat-soluble vitamin found in the inner mitochondrial membrane and is involved in electron transport chain that supplies energy to vital organs. Resveratrol is a natural polyphenolic compound that has been shown to offer protective effects against many cardiovascular, neurodegenerative diseases and cancer. The aim of this work was to study the effect of the combination of L-dopa, ubiquinone and resveratrol in comparison with L-dopa alone on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in mice. 50 albino mice were divided into 5 equal groups: Control untreated group, MPTP group, L-dopa + MPTP group, L-dopa + ubiquinone + MPTP group, L-dopa + resveratrol + MPTP group. Striatal dopamine, tumor necrosis factor alpha (TNF-α), glutathione reductase, malondialdehyde, nitric oxide, mitochondrial adenosine triphosphate (ATP), mitochondrial complex I activity and catalepsy score were measured. The combination between L-dopa and either ubiquinone or resveratrol induced significant increase in the striatal ATP, dopamine, glutathione reductase and mitochondrial complex I activity with significant decrease in striatal TNF-α level, nitric oxide and malondialdehyde level with significant improvement in the catalepsy score better than the group that received L-dopa alone compared to MPTP-treated group. In conclusion, the combination of L-dopa and ubiquinone or L-dopa and resveratrol had a better effect than L-dopa alone on MPTP-induced Parkinsonism in mice.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords