alexa Effect of Vanadium on TLR4 and TLR7 mRNA Expression in the Lymphoid Organs of Broilers | OMICS International | Abstract
ISSN: 2161-0444

Medicinal Chemistry
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Research Article

Effect of Vanadium on TLR4 and TLR7 mRNA Expression in the Lymphoid Organs of Broilers

Wei Cui, Hengmin Cui*, Xi Peng, Jing Fang, Zhicai Zuo, Xiaodong Liu and Bangyuan Wu

Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya’an 625014, China

*Corresponding Author:
Hengmin CuiPhD
Professor, College of Veterinary Medicine
Sichuan Agricultural University
Ya’an, Sichuan 625014, China
Tel: +86 13608264628
Fax: +86 0835 2882340
E-mail: [email protected]; [email protected]

Received date: April 09, 2012; Accepted date: August 13, 2012; Published date: August 16, 2012

Citation: Cui W, Cui H, Peng X, Fang J, Zuo Z, et al. (2012) Effect of Vanadium on TLR4 and TLR7 mRNA Expression in the Lymphoid Organs of Broilers. Med chem 2:103-106. doi:10.4172/2161-0444.1000123

Copyright: © 2012 Cui W, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


TLRs are important innate immune receptors. It has been found that vanadium can affect the immune function in broilers. However, vanadium action in the regulation of TLRs is unknown. A total of 420 one-day-old avian broilers were divided into six groups, and fed on a corn-soybean basal diet as control diet (vanadium 0.073 mg/kg) or the same diet supplemented with vanadium at the doses of 5, 15, 30, 45 and 60 mg/kg in the form of ammonium metavanadate. TLR4 and TLR7 mRNA expression in lymphoid organs of each group were studied by real time RT-PCR form. The results indicated that the TLR4 and TLR7 mRNA expression in thymus and TLR4 mRNA expression in bursa were down-regulated in the 60 mg/kg group. The TLR7 mRNA expression in bursa was down-regulated in 30 mg/kg, 45 mg/kg and 60 mg/kg groups, and up-regulated in the 5 mg/kg group. Also, the TLR4 and TLR7 mRNA expression in spleen was down-regulated in the 45 mg/kg and 60 mg/kg groups, and up-regulated in the 5 mg/kg group. The abovementioned results showed that dietary vanadium in excess of 30 mg/kg could down-regulate the TLR4 and TLR7 mRNA expression in lymphoid organs, which finally impaired innate immunity in broilers.


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