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ISSN: 2155-9880

Journal of Clinical & Experimental Cardiology
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Research Article

Effect of Vildagliptin on Atherosclerosis Progression in High Cholesterol –Fed Male Rabbits

Najah R Hadi*, Hussain Abdulkadhim, Ahmad Almudhafer, Sahar A Majeed
Department of Pharmacology and Therapeutics, Kufa College of Medicine, Kufa, po: 21 Iraq
Corresponding Author : Najah R Hadi
Department of Pharmacology and Therapeutics
Kufa College of Medicine, Kufa, po: 21, Iraq
Tel: 009647801241456
E-mail: [email protected]
Received May 02, 2013; Accepted June 10, 2013; Published June 12, 2013
Citation: Hadi NR, Abdulkadhim H, Almudhafer A, Majeed SA (2013) Effect of Vildagliptin on Atherosclerosis Progression in High Cholesterol –Fed Male Rabbits. J Clin Exp Cardiolog 4:249. doi: 10.4172/2155-9880.1000249
Copyright: © 2013 Hadi NR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Background: Atherosclerosis is a progressive disease of large and medium-sized arteries characterized by the accumulation of lipids and fibrous elements in the large arteries. Aim of the study: This study was undertaken to assess the effect of vildagliptin on the progression of atherosclerosis via interfering with inflammatory and oxidative pathways. Materials and Methods: 18 local domestic male rabbits were included in this study. The animals were randomly divided into three groups (6 rabbits for each group): Group I rabbits fed normal chow (oxiod) diet for 12 weeks. Group II rabbits fed 1% cholesterol enriched diet for 12 weeks. Group III rabbits fed with cholesterol enriched diet for 6 weeks, and then continued on cholesterol-enriched diet and treated with vildaglipin 50 mg/kg/day orally for the next 6 weeks. Blood samples were collected at the start of the study, at 6weeks of the study and then at the end of treatment course to measure Serum lipids profile [(TC), (TG), (HDL)], hsCRP and TNFα. At the end of the study the aorta were removed for measurement of aortic MDA, glutathione, sectioning for histopathology and measuring aortic intima- media thickness. Results: Treatment of rabbits with vildagliptin for 6 weeks results in a significant reduction (P<0.05) in serum level of TC, TG, hsCRP and TNFα and a significant increase (P<0.05) in serum HDL level. There was a significant reduction (P<0.05) in aortic MDA and intima-media thickness, in comparison to the rabbits in the induced untreated control group. vildagliptin treatment cause significant increment (P<0.05) in aortic GSH in comparison to induced untreated group. Regarding the histopathological results, vildagliptin treatment for 6 weeks results in a significant reduction (P<0.05) in atherosclerotic lesions in comparison to the induced untreated group and significant reduction in aortic intima- media thickness (P<0.05). Conclusions: Vildagliptin reduced atherosclerosis progression in hyperlipidemic rabbit via its effect on lipid parameters and interfering with inflammatory and oxidative stress pathway.

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